Aurora kinase A inhibition induces synthetic lethality in SMAD4-deficient colorectal cancer cells via spindle assembly checkpoint activation

Autor:	Changxiang Shi, Shishi Tao, Guowen Ren, Eun Ju Yang, Xiaodong Shu, Pui Kei Mou, Yifan Liu, Yongjun Dang, Xiaoling Xu, Joong Sup Shim
Rok vydání:	2022
Předmět:	Cancer Research Genetics Humans M Phase Cell Cycle Checkpoints Cell Cycle Checkpoints Colorectal Neoplasms Synthetic Lethal Mutations Molecular Biology Aurora Kinase A Smad4 Protein
Zdroj:	Oncogene. 41:2734-2748
ISSN:	1476-5594 0950-9232
DOI:	10.1038/s41388-022-02293-y
Popis:	SMAD4 loss-of-function mutations have been frequently observed in colorectal cancer (CRC) and are recognized as a drug target for therapeutic exploitation. In this study, we performed a synthetic lethal drug screening with SMAD4-isogenic CRC cells and found that aurora kinase A (AURKA) inhibition is synthetic lethal with SMAD4 loss. Inhibition of AURKA selectively inhibited the growth of SMAD4
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7b48fcc2f286457640f809e64e6955 https://doi.org/10.1038/s41388-022-02293-y Zobrazit plný text záznamu Full text from SpringerLink