Savings and extinction of conditioned eyeblink responses in fragile X syndrome
| Autor: | J.N. van der Geest, C. I. De Zeeuw, L. C. P. Govaerts, M. Vellema, Albertine Ellen Smit, Ben A. Oostra, Rob Willemsen, Frans VanderWerf, Sebastiaan K. E. Koekkoek |
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| Přispěvatelé: | Neurosciences, Clinical Genetics |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Cerebellum Fragile x medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities Audiology Extinction Psychological Developmental psychology Fragile X Mental Retardation Protein Young Adult Behavioral Neuroscience Genetics medicine Humans Learning Psychology human Biology Motor skill Intelligence Tests Intelligence quotient extinction savings Original Articles delay eyeblink conditioning Extinction (psychology) Middle Aged medicine.disease Conditioning Eyelid Fragile X syndrome medicine.anatomical_structure Neurology Eyeblink conditioning Motor Skills Data Interpretation Statistical Fragile X Syndrome Female Human medicine Motor learning |
| Zdroj: | Genes, brain and behavior Genes Brain and Behavior, 7(7), 770-777. Wiley-Blackwell Publishing Ltd Genes, Brain, and Behavior |
| ISSN: | 1601-1848 |
| Popis: | The fragile X syndrome (FRAXA) is the most widespread heritable form of mental retardation caused by the lack of expression of the fragile X mental retardation protein (FMRP). This lack has been related to deficits in cerebellum-mediated acquisition of conditioned eyelid responses in individuals with FRAXA. In the present behavioral study, long-term effects of deficiency of FMRP were investigated by examining the acquisition, savings and extinction of delay eyeblink conditioning in male individuals with FRAXA. In the acquisition experiment, subjects with FRAXA displayed a significantly poor performance compared with controls. In the savings experiment performed at least 6 months later, subjects with FRAXA and controls showed similar levels of savings of conditioned responses. Subsequently, extinction was faster in subjects with FRAXA than in controls. These findings confirm that absence of the FMRP affects cerebellar motor learning. The normal performance in the savings experiment and aberrant performance in the acquisition and extinction experiments of individuals with FRAXA suggest that different mechanisms underlie acquisition, savings and extinction of cerebellar motor learning. |
| Databáze: | OpenAIRE |
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