MicroRNA-96-5p represses breast cancer proliferation and invasion through Wnt/β-catenin signaling via targeting CTNND1
| Autor: | Yan-zhen Guo, Xiao-bing Chen, Shuang-shuang Guo, Xiao-hui Gao, Zhi-ye Zhang, Ya-li Zhang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Delta Catenin lcsh:Medicine Apoptosis Breast Neoplasms Wnt1 Protein Biology MMP7 Article Prognostic markers 03 medical and health sciences Breast cancer 0302 clinical medicine Cyclin D1 Downregulation and upregulation Cell Movement microRNA Biomarkers Tumor Tumor Cells Cultured medicine Humans Neoplasm Invasiveness lcsh:Science skin and connective tissue diseases beta Catenin Cell Proliferation Multidisciplinary CTNND1 lcsh:R Wnt signaling pathway Catenins Prognosis medicine.disease Phenotype Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Female lcsh:Q |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-019-56571-z |
| Popis: | Low miR-96-5p expression is characteristic of many cancers but its role in breast cancer (BCa) remains poorly defined. Here, the role of miR-96-5p in BC development was assessed. We demonstrate that exogenously expressing miR-96-5p inhibits the proliferative, migratory and invasive capacity of BCa cells. Mechanistically, miR-96-5p in BCa cells was found to target and downregulate catenin delta 1 (CTNND1) leading to decreased β-catenin expression, a loss of WNT11 signaling, reduced cyclin D1 levels and lower MMP7 expression. Exogenously expressing CTNND1 alleviated these effects. In summary, we are the first to reveal that miR-96-5p inhibits the proliferative, invasive and migratory phenotypes of BCa cells the targeting of CTNND1 and subsequent Wnt/β-catenin signaling. These data highlight miR-96-5p as a novel target for BC treatment. |
| Databáze: | OpenAIRE |
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