Catechol-O-Methyltransferase Val158Met Polymorphism and Antisaccade Eye Movements in Schizophrenia
| Autor: | Thordur Sigmundsson, Ulrich Ettinger, Andrés Ingason, Haraldur Magnus Haraldsson, Engilbert Sigurdsson, Hannes Petursson, Brynja B. Magnusdottir |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Psychosis Candidate gene medicine.medical_specialty Adolescent Genotype Dopamine Gene Dosage Single-nucleotide polymorphism Catechol O-Methyltransferase behavioral disciplines and activities Polymorphism Single Nucleotide Young Adult Methionine Reference Values Internal medicine mental disorders medicine Saccades Humans Genetic Predisposition to Disease Alleles Genetic Association Studies Genetics Psychiatric Status Rating Scales Catechol-O-methyl transferase Polymorphism Genetic Valine Middle Aged medicine.disease Frontal Lobe Isoenzymes Psychiatry and Mental health Endocrinology Frontal lobe Amino Acid Substitution Endophenotype Schizophrenia Female Antisaccade task Psychology rs4680 Regular Articles |
| Popis: | The catechol-O-methyltransferase (COMT) enzyme catabolizes dopamine. The val(158)met single nucleotide polymorphism (rs4680) in the COMT gene has received considerable attention as a candidate gene for schizophrenia as well as for frontally mediated cognitive functions. Antisaccade performance is a good measure of frontal lobe integrity. Deficits on the task are considered a trait marker for schizophrenia. The aim of this study was to investigate the association of COMT val(158)met polymorphism with antisaccade eye movements in schizophrenia patients and healthy controls. Schizophrenia patients (N = 105) and healthy controls (N = 95) underwent infrared oculographic assessment of antisaccades. Subjects were genotyped for COMT val(158)met and divided into 3 groups according to genotype (val/val, val/met, and met/met). Patients displayed significantly more reflexive errors, longer and more variable latency, and lower amplitude gain than controls (all P0.02). A greater number of val(158) alleles was associated with shorter (P = 0.045) and less variable (P = 0.028) antisaccade latency and, nonsignificantly, with lower reflexive error rate (P = 0.056). None of these variables showed a group-by-genotype interaction (P0.1). There were no significant associations of genotype with measures of amplitude gain or spatial error (P0.2). The results suggest that COMT val(158) carrier status is associated with better performance on the antisaccade task. Possible explanations of this finding are discussed. |
| Databáze: | OpenAIRE |
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