The role of qualea multiflora on mammary tumour cells and immune system

Autor: Carli, Camila B. de A. [UNESP], Quilles, Marcela Bassi [UNESP], Vilegas, Wagner [UNESP], Carlos, Iracilda Z. [UNESP]
Přispěvatelé: Universidade Estadual Paulista (UNESP)
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Popis: Made available in DSpace on 2022-04-29T08:49:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-09-01 Species of the genus Qualea are used by the Brazilian public as a natural anti-inflammatory. Based on this evidence, we evaluated the effects of terpene fractions (βF and TF) obtained from Qualea multiflora on nitric oxide production (Griess assay), cytokines (IL-1, IL-10, IL-12, and TNF-α) and the transcription factor NF-KB by peritoneal macrophages. Since there is a relationship between inflammation and cancer, the cytotoxicity of βF and TF against mammary tumoural cell lineage, and macrophages was evaluated. Inhibition levels close to 90% of the production of NO, IL-1, IL-12 and TNF-α; about 32% of NF-KB; and a large stimulation of IL-10 production (close to the positive control) by peritoneal macrophages were observed in response to βF and TF which are correlated with anti-inflammatory activity. Additionally, the samples showed exceptional cytotoxic activity against tumoural cells but not against macrophages. Since anti-inflammatory activity is important in tumour inhibition, further examination of potential anti-cancerous activity of Qualea multiflora is warranted. © 2013 Camila B. de A. Carli et al. UNESP - São Paulo State University Faculdade de Ciências Farmacêuticas, C. Postal 502, 14801-902, Araraquara, SP UNESP - São Paulo State University Instituto de Química de Araraquara, C. Postal 355, 14801-970, Araraquara, SP UNESP - São Paulo State University Faculdade de Ciências Farmacêuticas, C. Postal 502, 14801-902, Araraquara, SP UNESP - São Paulo State University Instituto de Química de Araraquara, C. Postal 355, 14801-970, Araraquara, SP
Databáze: OpenAIRE
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