Calmodulin and Calmodulin Binding Proteins in Dictyostelium: A Primer
| Autor: | Ryan J. Taylor, Michael A. Myre, Danton H. O'Day |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Models
Molecular calmodulin ved/biology.organism_classification_rank.species Protozoan Proteins Review Dictyostelium discoideum lcsh:Chemistry 0302 clinical medicine Dictyostelium Calcium ion binding lcsh:QH301-705.5 Spectroscopy Calcium signaling Regulation of gene expression 0303 health sciences biology Chemistry neurodegeneration General Medicine Calmodulin-binding proteins Computer Science Applications Biochemistry dictyostelium discoideum calmodulin binding proteins Protein Binding Calmodulin calcium signaling Catalysis calmodulin binding motifs Inorganic Chemistry 03 medical and health sciences Humans Physical and Theoretical Chemistry EF Hand Motifs Model organism Molecular Biology 030304 developmental biology Binding Sites Protozoan Infections ved/biology Organic Chemistry biology.organism_classification lcsh:Biology (General) lcsh:QD1-999 EF hands biology.protein Calcium Calmodulin-Binding Proteins heart arrythmia 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 4, p 1210 (2020) |
| ISSN: | 1422-0067 |
| Popis: | Dictyostelium discoideum is gaining increasing attention as a model organism for the study of calcium binding and calmodulin function in basic biological events as well as human diseases. After a short overview of calcium-binding proteins, the structure of Dictyostelium calmodulin and the conformational changes effected by calcium ion binding to its four EF hands are compared to its human counterpart, emphasizing the highly conserved nature of this central regulatory protein. The calcium-dependent and -independent motifs involved in calmodulin binding to target proteins are discussed with examples of the diversity of calmodulin binding proteins that have been studied in this amoebozoan. The methods used to identify and characterize calmodulin binding proteins is covered followed by the ways Dictyostelium is currently being used as a system to study several neurodegenerative diseases and how it could serve as a model for studying calmodulinopathies such as those associated with specific types of heart arrythmia. Because of its rapid developmental cycles, its genetic tractability, and a richly endowed stock center, Dictyostelium is in a position to become a leader in the field of calmodulin research. |
| Databáze: | OpenAIRE |
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