Design, synthesis, molecular modeling and neuroprotective effects of a new framework of cholinesterase inhibitors for Alzheimer’s disease

Autor:	Josélia A. Lima, Rackele Ferreira do Amaral, Tanos C. C. França, Daniel A. S. Kitagawa, Flavia Regina Souza Lima, Maria D. Vargas, Vanessa S. Zanon
Rok vydání:	2020
Předmět:	Molecular model 030303 biophysics Computational biology Disease Neuroprotection Structure-Activity Relationship 03 medical and health sciences chemistry.chemical_compound Alzheimer Disease Structural Biology Humans heterocyclic compounds Molecular Biology Butyrylcholinesterase Neuroinflammation Cholinesterase 0303 health sciences biology General Medicine Acetylcholinesterase Neuroprotective Agents chemistry Design synthesis biology.protein Cholinesterase Inhibitors
Zdroj:	Journal of Biomolecular Structure and Dynamics. 39:6112-6125
ISSN:	1538-0254 0739-1102
Popis:	In search of a novel class of compounds against Alzheimer's disease (AD), a new series of 7-chloro-aminoquinoline derivatives containing methylene spacers of different sizes between the 7-chloro-4-aminoquinoline nucleus and imino methyl substituted phenolic rings, and also their reduced analogues, were designed, synthesized and evaluated as neuroprotective agents for AD
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7220eb3f49c23d3e9a56f74397e07a https://doi.org/10.1080/07391102.2020.1796796 Zobrazit plný text záznamu