Increased central dopaminergic activity might be involved in the behavioral abnormality of cuprizone exposure mice
| Autor: | Li Zhang, Yanchuan Wu, Haoxiao Chang, Guangliang Chen, Jianghong Liu, Yifan Zhang, Houxi Ai, Fang Wang, Linlin Yin |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Dopamine Central nervous system Spatial memory 03 medical and health sciences Behavioral Neuroscience Cuprizone 0302 clinical medicine Internal medicine medicine Animals Dopamine transporter biology Behavior Animal Dopaminergic Spontaneous alternation Motor coordination Cortex (botany) Mice Inbred C57BL Disease Models Animal Oligodendroglia 030104 developmental biology Endocrinology medicine.anatomical_structure Memory Short-Term Astrocytes biology.protein Schizophrenia Microglia Psychology Neuroscience 030217 neurology & neurosurgery medicine.drug Demyelinating Diseases |
| Zdroj: | Behavioural brain research. 331 |
| ISSN: | 1872-7549 |
| Popis: | The neurotoxican cuprizone (CPZ, a copper chelator) has been used extensively to create a mouse model of demyelination. However, the effects on behavior of CPZ treatment have not been reported in C57BL/6 mice given a diet containing 0.4% CPZ within 3 weeks. Behavioral abnormalities were assessed using a range of test: Y-maze, spontaneous locomotor activity, rota-rod test, novel object recognition, climbing. Mice exposed to CPZ displayed more arm entrance, locomotor movements, and climbing behavior, suggesting an increase in central nervous system activity. However, no significant differences either in spontaneous alternation or latency to fall from the rotating drum were observed, demonstrating that spatial working memory or motor coordination and balance didn’t impair by CPZ short-term exposure. In addition, they showed higher dopamine levels and dopamine transporter expression in the cortex. Our findings indicate that increased central dopaminergic activity may relate to the behavioral abnormality in mice, and this CPZ short-term exposure with higher dose may offer a model to study some aspects of biology relevant to schizophrenia and other related disorders. |
| Databáze: | OpenAIRE |
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