Primed Lymphocytes are Boosted by Type II Collagen of their Host after Adoptive Transfer
| Autor: | N A Mitchison, S C Schneider, A Dietrich, E Rajnavölgyi |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Isoantigens Adoptive cell transfer medicine.medical_treatment Freund's Adjuvant Immunology Antigen presentation Dose-Response Relationship Immunologic Type II collagen Endogeny Biology Lymphocyte Activation Autoantigens Immunotherapy Adoptive Mice Immune system Species Specificity Antigen medicine Animals Immunology and Allergy Lymphocytes Antigen Presentation Arthritis Immunotherapy T lymphocyte Mice Inbred C57BL Mice Inbred DBA Cattle Immunization Collagen Chickens Spleen |
| Zdroj: | Journal of Autoimmunity. 7:601-609 |
| ISSN: | 0896-8411 |
| DOI: | 10.1006/jaut.1994.1044 |
| Popis: | A central question in understanding autoimmunity is whether an endogenous self-antigen can drive an immune response initially triggered by a foreign one. This possibility is here tested by adoptive transfer, in which T and B cells from mice primed with foreign type II collagen were transferred into irradiated syngeneic hosts. Previous work with other protein antigens has established that primed cells normally respond only if boosted after transfer with antigen. In the present case, and in respect only to that portion of the antibody response able to bind to endogenous type II collagen, that requirement did not hold. This indicates that the anti-self component is indeed driven by endogenous antigen, which the transferred lymphocytes presumably obtain from their adoptive hosts. The transfers were carried out in C57BL10.A x DBA/1 mice using donors primed with either chick or bovine collagen, and the non-boosted responses, presumably driven by endogenous antigen, could be followed in a proportion of the recipients for as long as 45 days. |
| Databáze: | OpenAIRE |
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