Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer:Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses

Autor: Khankari, Nikhil K., Shu, Xiao Ou, Wen, Wanqing, Kraft, Peter, Lindström, Sara, Peters, Ulrike, Schildkraut, Joellen, Schumacher, Fredrick, Bofetta, Paolo, Risch, Angela, Bickeböller, Heike, Amos, Christopher I., Easton, Douglas, Eeles, Rosalind A., Gruber, Stephen B., Haiman, Christopher A., Hunter, David J., Chanock, Stephen J., Pierce, Brandon L., Zheng, Wei, Blalock, Kendra, Campbell, Peter T., Casey, Graham, Conti, David V., Edlund, Christopher K., Figueiredo, Jane, James Gauderman, W., Gong, Jian, Green, Roger C., Harju, John F., Harrison, Tabitha A., Jacobs, Eric J., Jenkins, Mark A., Jiao, Shuo, Li, Li, Lin, Yi, Manion, Frank J., Moreno, Victor, Mukherjee, Bhramar, Raskin, Leon, Schumacher, Fredrick R., Seminara, Daniela, Severi, Gianluca, Stenzel, Stephanie L., Thomas, Duncan C., Hopper, John L., Southey, Melissa C., Makalic, Enes, Schmidt, Daniel F., Fletcher, Olivia, Peto, Julian, Gibson, Lorna, dos Santos Silva, Isabel, Ahsan, Habib, Whittemore, Alice, Waisfisz, Quinten, Meijers-Heijboer, Hanne, Adank, Muriel, van der Luijt, Rob B., Uitterlinden, Andre G., Hofman, Albert, Meindl, Alfons, Schmutzler, Rita K., Müller-Myhsok, Bertram, Lichtner, Peter, Nevanlinna, Heli, Muranen, Taru A., Aittomäki, Kristiina, Blomqvist, Carl, Chang-Claude, Jenny, Hein, Rebecca, Dahmen, Norbert, Beckman, Lars, Crisponi, Laura, Hall, Per, Czene, Kamila, Irwanto, Astrid, Liu, Jianjun, Easton, Douglas F., Turnbull, Clare, Rahman, Nazneen, Eeles, Rosalind, Kote-Jarai, Zsofia, Muir, Kenneth, Giles, Graham, Neal, David, Donovan, Jenny L., Hamdy, Freddie C., Wiklund, Fredrik, Gronberg, Henrik, Haiman, Christopher, Schumacher, Fred, Travis, Ruth, Riboli, Elio, Hunter, David, Gapstur, Susan, Berndt, Sonja, Chanock, Stephen, Han, Younghun, Su, Li, Wei, Yongyue, Hung, Rayjean J., Brhane, Yonathan, McLaughlin, John, Brennan, Paul, McKay, James D., Rosenberger, Albert, Houlston, Richard S., Caporaso, Neil, Teresa Landi, Maria, Heinrich, Joachim, Wu, Xifeng, Ye, Yuanqing, Christiani, David C.
Přispěvatelé: Human genetics, CCA - Evaluation of Cancer Care, Eeles, Rosalind A [0000-0002-7472-5384], Apollo - University of Cambridge Repository
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Oncology
Male
Lung Neoplasms
Social Sciences
Genome-wide association study
Biochemistry
0302 clinical medicine
Sociology
Odds Ratio
Prospective Studies
Aged
80 and over

Prostate Diseases
11 Medical And Health Sciences
General Medicine
Genomics
3. Good health
030220 oncology & carcinogenesis
Meta-analysis
Physical Sciences
Transdisciplinary Research in Cancer of the Lung (TRICL)
Medicine
DIFFERENT ANATOMIC SITES
BODY-MASS-INDEX
Statistics (Mathematics)
medicine.medical_specialty
03 medical and health sciences
Exocrine Glands
SDG 3 - Good Health and Well-being
Genome-Wide Association Studies
Genetics
Humans
Statistical Methods
Molecular Biology
RECTAL-CANCER
Aged
Science & Technology
Biology and Life Sciences
Computational Biology
Genetic Variation
Odds ratio
Mendelian Randomization Analysis
medicine.disease
Genitourinary Tract Tumors
030104 developmental biology
Relative risk
OLDER WOMEN
Prostate Gland
Mathematics
Meta-Analysis
Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE)
0301 basic medicine
Bioinformatics
Lung and Intrathoracic Tumors
Mathematical and Statistical Techniques
NETHERLANDS COHORT
Consortia
Risk Factors
GROWTH-FACTOR (IGF)-I
Medicine and Health Sciences
Prospective cohort study
Prostate Cancer
Middle Aged
Research Design
Female
Anatomy
Colorectal Neoplasms
Life Sciences & Biomedicine
NORWEGIAN MEN
Research Article
Biotechnology
Adult
Urology
IGF-BINDING PROTEINS
Research and Analysis Methods
Young Adult
Medicine
General & Internal

Discovery
Biology
and Risk of Inherited Variants in Breast Cancer (DRIVE)

General & Internal Medicine
Internal medicine
Mendelian randomization
medicine
Journal Article
Colorectal Transdisciplinary Study (CORECT)
Lung cancer
Colorectal Cancer
business.industry
Cancers and Neoplasms
Prostatic Neoplasms
JAPANESE MEN
Human Genetics
Cell Biology
Genome Analysis
Body Height
Prostate cancer
Lung and intrathoracic tumors
Prospective studies
Colorectal cancer
Prostate gland
Genome-wide association studies
FOLLOW-UP
business
Genome-Wide Association Study
Zdroj: Khankari, N K, Shu, X O, Wen, W, Kraft, P, Lindström, S, Peters, U, Schildkraut, J, Schumacher, F, Bofetta, P, Risch, A, Bickeböller, H, Amos, C I, Easton, D, Eeles, R A, Gruber, S B, Haiman, C A, Hunter, D J, Chanock, S J, Pierce, B L, Zheng, W, Blalock, K, Campbell, P T, Casey, G, Conti, D V, Edlund, C K, Figueiredo, J, James Gauderman, W, Gong, J, Green, R C, Harju, J F, Harrison, T A, Jacobs, E J, Jenkins, M A, Jiao, S, Li, L, Lin, Y, Manion, F J, Moreno, V, Mukherjee, B, Raskin, L, Schumacher, F R, Seminara, D, Severi, G, Stenzel, S L, Thomas, D C, Hopper, J L, Southey, M C, Makalic, E, Schmidt, D F, Fletcher, O, Peto, J, Gibson, L, dos Santos Silva, I, Ahsan, H, Whittemore, A, Waisfisz, Q, Meijers-Heijboer, H, Adank, M, van der Luijt, R B, Uitterlinden, A G, Hofman, A, Meindl, A, Schmutzler, R K, Müller-Myhsok, B, Lichtner, P, Nevanlinna, H, Muranen, T A, Aittomäki, K, Blomqvist, C, Chang-Claude, J, Hein, R, Dahmen, N, Beckman, L, Crisponi, L, Hall, P, Czene, K, Irwanto, A, Liu, J, Easton, D F, Turnbull, C, Rahman, N, Eeles, R, Kote-Jarai, Z, Muir, K, Giles, G, Neal, D, Donovan, J L, Hamdy, F C, Wiklund, F, Gronberg, H, Haiman, C, Schumacher, F, Travis, R, Riboli, E, Hunter, D, Gapstur, S, Berndt, S, Chanock, S, Han, Y, Su, L, Wei, Y, Hung, R J, Brhane, Y, McLaughlin, J, Brennan, P, McKay, J D, Rosenberger, A, Houlston, R S, Caporaso, N, Teresa Landi, M, Heinrich, J, Wu, X, Ye, Y & Christiani, D C 2016, ' Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer : Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses ', PLoS Medicine, vol. 13, no. 9, e1002118 . https://doi.org/10.1371/journal.pmed.1002118
PLoS Medicine, 13(9). Public Library of Science
PLoS Medicine
PLoS Medicine, 13(9):e1002118. Public Library of Science
PLoS medicine
PLoS Medicine, Vol 13, Iss 9, p e1002118 (2016)
ISSN: 1549-1277
DOI: 10.1371/journal.pmed.1002118
Popis: Background Observational studies examining associations between adult height and risk of colorectal, prostate, and lung cancers have generated mixed results. We conducted meta-analyses using data from prospective cohort studies and further carried out Mendelian randomization analyses, using height-associated genetic variants identified in a genome-wide association study (GWAS), to evaluate the association of adult height with these cancers. Methods and Findings A systematic review of prospective studies was conducted using the PubMed, Embase, and Web of Science databases. Using meta-analyses, results obtained from 62 studies were summarized for the association of a 10-cm increase in height with cancer risk. Mendelian randomization analyses were conducted using summary statistics obtained for 423 genetic variants identified from a recent GWAS of adult height and from a cancer genetics consortium study of multiple cancers that included 47,800 cases and 81,353 controls. For a 10-cm increase in height, the summary relative risks derived from the meta-analyses of prospective studies were 1.12 (95% CI 1.10, 1.15), 1.07 (95% CI 1.05, 1.10), and 1.06 (95% CI 1.02, 1.11) for colorectal, prostate, and lung cancers, respectively. Mendelian randomization analyses showed increased risks of colorectal (odds ratio [OR] = 1.58, 95% CI 1.14, 2.18) and lung cancer (OR = 1.10, 95% CI 1.00, 1.22) associated with each 10-cm increase in genetically predicted height. No association was observed for prostate cancer (OR = 1.03, 95% CI 0.92, 1.15). Our meta-analysis was limited to published studies. The sample size for the Mendelian randomization analysis of colorectal cancer was relatively small, thus affecting the precision of the point estimate. Conclusions Our study provides evidence for a potential causal association of adult height with the risk of colorectal and lung cancers and suggests that certain genetic factors and biological pathways affecting adult height may also affect the risk of these cancers.
In a Mendelian randomisation study Pierce and colleagues show a genetic association between adult height and increased risk of colorectal and lung cancer.
Author Summary Why Was This Study Done? Several previous observational studies have examined the association between adult height and risk of cancers of the lung, colon/rectum, and prostate; however, it remains unclear whether adult height is indeed related to the risk of these cancers. What Did the Researchers Do and Find? We conducted a systematic review and meta-analysis of prospective cohort studies that examined the association between adult height and the risk of colorectal, lung, and prostate cancers. To overcome inherent limitations of observational study designs, we conducted Mendelian randomization analyses using genetic data generated from a large multi-center consortium study including 47,800 cases and 81,353 controls. In the meta-analysis of the prospective observational studies, we found a 12% increased risk of colorectal cancer, a 7% increased risk of prostate cancer, and a 6% increased risk of lung cancer for every ten-centimeter increase in height, and this increased risk was corroborated in the Mendelian randomization analyses for colorectal (58%) and lung cancer (10%). What Do These Findings Mean? Our study provides strong evidence for an association between adult height and risk of colorectal and lung cancer, and suggests that certain genetic and biological factors that affect height may also affect the risk of these cancers. However, our meta-analysis was limited to published studies, and the sample size for the Mendelian randomization analysis for colorectal cancer was relatively small, affecting the precision of the risk estimate.
Databáze: OpenAIRE