Rapid 18F-labeling via Pd-catalyzed S-arylation in aqueous medium
| Autor: | Raisa Krasikova, Heike Endepols, Dieter Willbold, Swen Humpert, Boris D. Zlatopolskiy, Lothar Gremer, Elizaveta A. Urusova, Mohamed A Omrane, Bernd Neumaier |
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| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Chromatography biology Aqueous medium 010405 organic chemistry Metals and Alloys Peptide General Chemistry Glutathione urologic and male genital diseases 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound chemistry 18f labeling ddc:540 Materials Chemistry Ceramics and Composites biology.protein Bovine serum albumin |
| Zdroj: | Chemical communications 57, 3547-3550 (2021). doi:10.1039/D1CC00745A |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | We report radiolabeling of thiol-containing substrates via Pd-catalyzed S-arylation with 2-[18F]fluoro-5-iodopyridine, which is readily accessible using the “minimalist” radiofluorination method. The practicality of the procedure was confirmed by preparation of a novel PSMA-specific PET-tracer as well as labeling of glutathione, Aβ oligomer-binding RD2 peptide, bovine serum albumin and PSMA I&S. |
| Databáze: | OpenAIRE |
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