A potential Rho GEF and Rac GAP for coupled Rac and Rho cycles during mesenchymal-to-epithelial-like transitions
| Autor: | André Le Bivic, Christopher P. Toret |
|---|---|
| Přispěvatelé: | Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS), Réseau National des Systèmes Complexes (RNSC), Centre National de la Recherche Scientifique (CNRS)-CPU-CGE-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de la Recherche Agronomique (INRA)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Aix Marseille Université (AMU)-Collège de France (CdF)-Centre National de la Recherche Scientifique (CNRS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CGE-CPU-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
dorsal closure
animal structures elmo-dock [SDV]Life Sciences [q-bio] GTPase [SDV.BC]Life Sciences [q-bio]/Cellular Biology Biology RhoGEF64C Biochemistry RhoGAP92B GAP Proteins 03 medical and health sciences 0302 clinical medicine mesenchymal-to-epithelial transition RNA interference Rho [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB] RhoGAP19D ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences Brief Report Mesenchymal stem cell fungi elmo-mbc Cell Biology Net1 Dorsal closure Cell biology Rac 030220 oncology & carcinogenesis Rho Guanine Nucleotide Exchange Factors |
| Zdroj: | Small GTPases Small GTPases, Taylor & Francis, 2018, pp.1-7. ⟨10.1080/21541248.2018.1502592⟩ Small GTPases, 2021, 12 (1), pp.13-19. ⟨10.1080/21541248.2018.1502592⟩ Small GTPases, 2018, pp.1-7. ⟨10.1080/21541248.2018.1502592⟩ Small GTPases, Taylor & Francis, 2021, 12 (1), pp.13-19. ⟨10.1080/21541248.2018.1502592⟩ |
| ISSN: | 2154-1256 |
| DOI: | 10.1080/21541248.2018.1502592⟩ |
| Popis: | International audience; The leading edge-to-cadherin contact transitions that occur during metazoan developmental processes and disease states require fine coordination of Rac and Rho pathways. Recently the elmo-mbc complex, a Rac GEF and RhoGAP19D, a Rho GAP were identified as key, conserved regulators that link Rac and Rho during these transitions. The corresponding Rho GEF and Rac GAP remain hidden amongst the large family of GEF and GAP proteins. Identification of these regulators is essential to understand GTPase coordination during these transitions. Here we find two candidates based on the mammalian literature and use RNAi to explore the fly ortholog effects on the dorsal closure epidermis. RhoGEF64C and RhoGAP92B are strong contenders to couple Rac and Rho during mesenchymal-to-epithelial-like transitions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|