Failure of repetition suppression and memory encoding in aging and Alzheimer’s disease
| Autor: | Jackie O'Brien, Reisa A. Sperling, Kelly O'Keefe, Maija Pihlajamäki, Deborah Blacker |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Aging medicine.medical_specialty Cognitive Neuroscience Neuropsychological Tests Audiology Article Temporal lobe Association Young Adult Behavioral Neuroscience Cellular and Molecular Neuroscience Cognition Alzheimer Disease Memory Image Processing Computer-Assisted medicine Humans Memory impairment Radiology Nuclear Medicine and imaging Young adult Association (psychology) Aged Psychiatric Status Rating Scales medicine.diagnostic_test Neuropsychology Recognition Psychology medicine.disease Magnetic Resonance Imaging Temporal Lobe Psychiatry and Mental health Neurology Mental Recall Female Neurology (clinical) Alzheimer's disease Psychology Functional magnetic resonance imaging psychological phenomena and processes Cognitive psychology |
| Zdroj: | Brain Imaging and Behavior. 5:36-44 |
| ISSN: | 1931-7565 1931-7557 |
| Popis: | The suppression of neural activity in the medial temporal lobe (MTL) has been suggested as a marker of successful recognition of familiarity in healthy subjects, but to be impaired in patients with Alzheimer’s disease (AD). In this study, we investigated whether the ability to suppress MTL activity during repeated exposure to face-name pairs was related to the ability to successfully encode novel associations in 90 individuals ranging from healthy young and older subjects to mildly impaired elderly and AD patients. Activity in the anterior MTL during Repeated stimuli was inversely related to performance in post-scan associative recognition for the Novel face-name pairs. In a subset (n=60) of subjects undergoing more detailed neuropsychological testing, greater MTL Repeated activity was correlated with worse word-list delayed recall performance. Failure of response suppression to familiar information may be a sensitive marker of MTL dysfunction and memory impairment in aging and prodromal AD. |
| Databáze: | OpenAIRE |
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