Virological rather than host factors are associated with transaminase levels among HIV/HCV-coinfected patients
| Autor: | Marina Núñez, Leticia Pérez-Saleme, Nathan J. Shores, Ivana Maida |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Multivariate analysis Genotype Immunology Human immunodeficiency virus (HIV) Host factors HIV Infections Dermatology Comorbidity Hepacivirus medicine.disease_cause Gastroenterology White People Transaminase Liver disease Internal medicine medicine North Carolina Humans Alanine aminotransferase Retrospective Studies business.industry HIV Alanine Transaminase Hepatitis C Viral Load medicine.disease digestive system diseases Black or African American Infectious Diseases Cross-Sectional Studies Italy Multivariate Analysis Female business |
| Zdroj: | Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002). 9(1) |
| ISSN: | 1545-1097 |
| Popis: | Alanine aminotransferase (ALT) is a routine parameter in the assessment and monitoring of chronic hepatitis C viral (HCV) infection. Hepatitis C virus-infected African Americans (AAs) have been reported to have lower ALT levels. In this retrospective, cross-sectional, multicenter study, host and virological factors possibly associated with ALT levels were analyzed by multivariate regression analyses among HIV/HCV-coinfected patients. Of the 289 patients included, 142 were African Americans and 144 Caucasians. In multivariate analysis, only HCV genotype 3 (B 0.2 [95% CI 13.39-52.33]; P = .001) and HCV RNA >500 000 IU/mL (B 3.1 [95% CI 7.67-34.75]; P = .002) were independent predictors of higher ALT levels. Per the American Association for the Study of Liver Disease (AASLD) definition, 18.2% had ALT levels within normal limits. Male sex and HCV RNA |
| Databáze: | OpenAIRE |
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