Auditory N100 gating in patients with schizophrenia: A systematic meta-analysis
| Autor: | Timm Rosburg |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Gating Stimulus (physiology) Audiology 03 medical and health sciences 0302 clinical medicine Auditory stimulation Salience (neuroscience) Physiology (medical) medicine Humans In patient Child N100 Sensory gating business.industry Middle Aged Sensory Gating Sensory Systems 030227 psychiatry medicine.anatomical_structure Neurology Meta-analysis Evoked Potentials Auditory Schizophrenia Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Clinical Neurophysiology. 129:2099-2111 |
| ISSN: | 1388-2457 |
| Popis: | Objective The study sought to assess the presence of auditory N100 gating deficits in patients with schizophrenia by meta-analysis. Methods Literature was screened for studies on patients with schizophrenia that used the paired-click paradigm and reported N100 data. Both electroencephalographic and magnetoencephalographic studies were considered. N100 gating measures as well as the N100 amplitudes to the initial and repeated stimulus were extracted and subjected to a meta-analysis. Results The literature research revealed 29 studies, reporting either N100 gating or N100 amplitude measures in paired-click experiments. Patients with schizophrenia exhibited less N100 gating than healthy controls across studies (mean g = −0.405, SE = 0.051). However, what appeared as a gating deficit in patients was due to reduced N100 amplitudes to the initial stimulus in this group (mean g = 0.610, SE = 0.075). Patients and controls did not differ in their N100 amplitudes to the repeated stimulus (mean g = 0.042, SE = 0.066). Conclusion There is no evidence for an auditory N100 gating deficit in schizophrenia, but for an impaired N100 response recovery. Significance Previous findings on impaired N100 gating in schizophrenia patients reflect deficient processing of auditory salience rather than defective inhibition of repeating redundant auditory stimulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect