Death sentence: The tale of a fallen endoplasmic reticulum
| Autor: | Eric Chevet, Elodie Lafont, Eoghan P. McGrath, Federica G. Centonze, Tony Avril |
|---|---|
| Přispěvatelé: | Chemistry, Oncogenesis, Stress and Signaling (COSS), Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CRLCC Eugène Marquis (CRLCC), This work was funded by grants from Institut National du Cancer (INCa PLBIO), Fondation pour la Recherche Médicale (FRM, équipe labellisée 2018), Agence Nationale de la Recherche (eRARE, eranet) to EC, and la Ligue Contre le Cancer (comités 35, 56 & 85 -AAP2019) to TA. EMG was funded by an Institut de Neurosciences Cliniques de Rennes (INCR) award. EL was supported by funds from the Fondation ARC and Fondation de France., Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Jonchère, Laurent |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cell death Programmed cell death Apoptosis [SDV.CAN]Life Sciences [q-bio]/Cancer Biology Unfolded protein response 03 medical and health sciences 0302 clinical medicine [SDV.CAN] Life Sciences [q-bio]/Cancer Autophagy Pyroptosis Animals Humans Ferroptosis Molecular Biology Mechanism (biology) Endoplasmic reticulum Cell Biology Endoplasmic Reticulum Stress Cell biology 030104 developmental biology Gene Expression Regulation 030220 oncology & carcinogenesis Protein folding |
| Zdroj: | Biochimica et Biophysica Acta-Molecular Cell Research Biochimica et Biophysica Acta-Molecular Cell Research, 2021, 1868 (6), pp.119001. ⟨10.1016/j.bbamcr.2021.119001⟩ Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2021, 1868 (6), pp.119001. ⟨10.1016/j.bbamcr.2021.119001⟩ |
| ISSN: | 0167-4889 |
| Popis: | International audience; Endoplasmic Reticulum (ER) stress signaling is an adaptive mechanism triggered when protein folding demand overcomes the folding capacity of this compartment, thereby leading to the accumulation of improperly folded proteins. This stress signaling pathway is named the Unfolded Protein Response (UPR) and aims at restoring ER homeostasis. However, if this fails, mechanisms orienting cells towards death processes are initiated. Herein, we summarize the most recent findings connecting ER stress and the UPR with identified death mechanisms including apoptosis, necrosis, pyroptosis, ferroptosis, and autophagy. We highlight new avenues that could be investigated and controlled through actionable mechanisms in physiology and pathology. |
| Databáze: | OpenAIRE |
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