Efficacy and safety of biapenem in treatment of infectious disease: a meta-analysis of randomized controlled trials
| Autor: | Yongmei Zhang, Weijiao Yin, Tongsheng Wang, Yimin Mao, Guangsheng Pei, Yuxia Sun |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Carbapenem medicine.drug_class 030106 microbiology Antibiotics Cochrane Library Communicable Diseases Meropenem law.invention 03 medical and health sciences 0302 clinical medicine Anti-Infective Agents Randomized controlled trial law medicine Humans Pharmacology (medical) 030212 general & internal medicine Intensive care medicine Biapenem Randomized Controlled Trials as Topic Pharmacology Respiratory tract infections business.industry Treatment Outcome Infectious Diseases Oncology Meta-analysis Thienamycins Safety business medicine.drug |
| Zdroj: | Journal of Chemotherapy. 28:28-36 |
| ISSN: | 1973-9478 1120-009X |
| Popis: | Biapenem is a parenteral carbapenem antibiotic that has powerful antibacterial activity. The aim of this study is to evaluate the efficacy and safety of biapenem for the treatment of infection diseases.We performed a meta-analysis of published randomized-controlled trials (RCTs) identified in Embase, PubMed, and Cochrane library that compared the efficacy and safety of biapenem with other antibiotic regimes for the treatment of patients with infections.Eight RCTs were included in the meta-analysis, involving totally 1685 patients with lower respiratory tract infections (LRTIs), complicated urinary tract infections (cUTIs), and complicated intra-abdominal infections (cIAIs). There was no difference found between the patients with LRTIs, cUTIs, or cIAIs treated with biapenem and comparators, regarding treatment success and adverse events.This meta-analysis provides evidence that biapenem can be used as effectively and safely as imipenem-cilstatin or meropenem, for the treatment of patients with LRTIs, cUTIs, and cIAIs. It may be a considerable option for the treatment of these infections. |
| Databáze: | OpenAIRE |
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