Geranylgeraniol Is a Potent Inducer of Apoptosis in Tumor Cells
| Autor: | Hidekazu Ohizumi, Yutaka Masuda, Kazuyasu Nakaya, Shigeo Nakajo, Shigemitsu Ohsawa, I. Sakai |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Leukemia
Myeloid DNA synthesis Chemistry Apoptosis General Medicine Adenocarcinoma medicine.disease Biochemistry chemistry.chemical_compound medicine.anatomical_structure Geranylgeraniol hemic and lymphatic diseases Colonic Neoplasms Tumor Cells Cultured medicine Cancer research Humans DNA fragmentation Inducer Diterpenes Molecular Biology K562 cells |
| Zdroj: | The Journal of Biochemistry. 117:11-13 |
| ISSN: | 1756-2651 0021-924X |
| DOI: | 10.1093/oxfordjournals.jbchem.a124695 |
| Popis: | We screened various isoprenoids to find inducers of apoptosis for human leukemia HL-60 cells, and found that GGO (geranylgeraniol) had the most potent apoptosis-inducing activity, as judged from DNA fragmentation in HL-60 cells. The apoptosis-inducing activity of GGO is concentration- and time-dependent. DNA synthesis by HL-60 cells was selectively inhibited on treatment with GGO. Besides HL-60 cells, apoptosis was induced by GGO in various tumor cell lines, including human myeloid multipotential leukemia K562, lymphoblastic leukemia Molt3, and colon adenocarcinoma COLO320 DM. |
| Databáze: | OpenAIRE |
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