Comprehensive review of lipocalin 2-mediated effects in lung inflammation
| Autor: | Stephanie Guardado, Tara M. Nordgren, Daniel Ojeda-Juárez, Marcus Kaul |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
Physiology Neutrophils Iron Inflammation Apoptosis Review Lipocalin Mice Lipocalin-2 Immunity Cell Movement Physiology (medical) Medicine Animals Humans Lung Innate immune system Bacteria business.industry Macrophages Cell Biology Pneumonia Immunity Innate Inflammatory mediator Neutrophil gelatinase-associated lipocalin medicine.anatomical_structure Immunology medicine.symptom Inflammation Mediators business |
| Zdroj: | Am J Physiol Lung Cell Mol Physiol |
| Popis: | Lipocalin-2 (LCN2) is an inflammatory mediator best known for its role as an innate acute-phase protein. LCN2 mediates the innate immune response to pathogens by sequestering iron, thereby inhibiting pathogen growth. Although LCN2 and its bacteriostatic properties are well studied, other LCN2 functions in the immune response to inflammatory stimuli are less well understood, such as its role as a chemoattractant and involvement in the regulation of cell migration and apoptosis. In the lungs, most studies thus far investigating the role of LCN2 in the immune response have looked at pathogenic inflammatory stimuli. Here, we compile data that explore the role of LCN2 in the immune response to various inflammatory stimuli in an effort to differentiate between protective versus detrimental roles of LCN2. |
| Databáze: | OpenAIRE |
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