Translational Utility of the Nonhuman Primate Model
| Autor: | Alice F. Tarantal, Dennis J. Hartigan-O’Connor, Stephen C. Noctor |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pediatric
Inflammation Translation Cognitive Neuroscience Inflammatory and immune system Placenta Neurodevelopment Reproductive health and childbirth Perinatal Period - Conditions Originating in Perinatal Period Macaca mulatta Fetus Immune system Infectious Diseases Good Health and Well Being Pregnancy Ontogeny Rhesus monkey Animals Humans Radiology Nuclear Medicine and imaging Female Neurology (clinical) Biological Psychiatry |
| Zdroj: | Biological psychiatry. Cognitive neuroscience and neuroimaging, vol 7, iss 5 |
| ISSN: | 2451-9030 |
| Popis: | Nonhuman primates are essential for the study of human disease and to explore the safety of new diagnostics and therapies proposed for human use. They share similar genetic, physiologic, immunologic, reproductive, and developmental features with humans and thus have proven crucial for the study of embryonic/fetal development, organ system ontogeny, and the role of the maternal-placental-fetal interface in health and disease. The fetus may be exposed to a variety of inflammatory stimuli including infectious microbes as well as maternal inflammation, which can result from infections, obesity, or environmental exposures. Growing evidence supports that inflammation is a mediator of fetal programming and that the maternal immune system is tightly integrated with fetal-placental immune responses that may set a postnatal path for future health or disease. This review addresses some of the unique features of the nonhuman primate model system, specifically the rhesus monkey (Macaca mulatta), and importance of the species for studies focused on organ system ontogeny and the impact of viral teratogens in relation to development and congenital disorders. |
| Databáze: | OpenAIRE |
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