Efficacy of Topical Epinephrine in Tympanoplasty
| Autor: | Rex S Haberman, Carolyn O. Dirain, Patrick J. Antonelli, Marna A. List |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Mean arterial pressure Adolescent Epinephrine medicine.medical_treatment Administration Topical Blood Loss Surgical Blood Pressure 03 medical and health sciences Young Adult 0302 clinical medicine Tympanoplasty Heart Rate Heart rate medicine Humans Vasoconstrictor Agents Prospective Studies 030223 otorhinolaryngology Adverse effect Child Aged Aged 80 and over Dose-Response Relationship Drug business.industry Middle Aged Hemostasis Surgical Blood pressure Treatment Outcome Otorhinolaryngology Vasoconstriction Anesthesia Hemostasis Child Preschool Female medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | The LaryngoscopeBIBLIOGRAPHY. 131(10) |
| ISSN: | 1531-4995 |
| Popis: | OBJECTIVES/HYPOTHESIS To compare the hemostatic effects of commonly used concentrations of topical epinephrine in tympanoplasty. STUDY DESIGN Prospective, randomized, controlled clinical trial. METHODS Patients undergoing tympanoplasty were randomized to receive topical epinephrine at 1:1,000 or 1:10,000. With the investigators blinded, hemostasis was assessed with a modified Boezaart scale. Vasoconstriction was measured by laser Doppler. Blood pressure and pulse were tracked. RESULTS Thirty patients, 4 to 84 years old, were studied, with 15 patients per group. Boezaart scores dropped a mean of 67% and 62% with 1:1,000 and 1:10,000, respectively (P = .44). Capillary blood flow decreased a mean of 50.4% and 50.9% with 1:1,000 and 1:10,000, respectively (P = .95). The mean change in heart rate and mean arterial pressure after topical epinephrine exposure were -4.9 and -0.73 beats per minute (P = .15), and -0.60 and -0.73 mmHg (P = .96) for 1:1,000 and 1:10,000 respectively. No adverse events occurred in either group. CONCLUSIONS Topical epinephrine at 1:10,000 has hemostatic efficacy comparable to 1:1,000 in tympanoplasty. Although both concentrations appear safe, use of topical epinephrine 1:10,000 should be considered over 1:1,000 to minimize the potential for adverse events. LEVEL OF EVIDENCE 2 Laryngoscope, 131:2319-2322, 2021. |
| Databáze: | OpenAIRE |
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