Whole-Genome Duplication and the Functional Diversification of Teleost Fish Hemoglobins
| Autor: | Jay F. Storz, Mariana F. Nery, Juan C. Opazo, Federico G. Hoffmann, G. Tyler Butts |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
gene family evolution
0106 biological sciences Lineage (evolution) Gene Expression beta-Globins Biology Synteny 010603 evolutionary biology 01 natural sciences Evolution Molecular 03 medical and health sciences alpha-Globins Phylogenetics genome duplication Gene duplication Genetics Animals convergent evolution Molecular Biology Gene Phylogeny Discoveries Ecology Evolution Behavior and Systematics 030304 developmental biology Segmental duplication 0303 health sciences Genome Phylogenetic tree Gene Expression Profiling Fishes gene duplication Computational Biology Genetic Variation Genomics Gene expression profiling Evolutionary biology Multigene Family Sequence Alignment |
| Zdroj: | Molecular Biology and Evolution |
| ISSN: | 1537-1719 0737-4038 |
| DOI: | 10.1093/molbev/mss212 |
| Popis: | Subsequent to the two rounds of whole-genome duplication that occurred in the common ancestor of vertebrates, a third genome duplication occurred in the stem lineage of teleost fishes. This teleost-specific genome duplication (TGD) is thought to have provided genetic raw materials for the physiological, morphological, and behavioral diversification of this highly speciose group. The extreme physiological versatility of teleost fish is manifest in their diversity of blood-gas transport traits, which reflects the myriad solutions that have evolved to maintain tissue O(2) delivery in the face of changing metabolic demands and environmental O(2) availability during different ontogenetic stages. During the course of development, regulatory changes in blood-O(2) transport are mediated by the expression of multiple, functionally distinct hemoglobin (Hb) isoforms that meet the particular O(2)-transport challenges encountered by the developing embryo or fetus (in viviparous or oviparous species) and in free-swimming larvae and adults. The main objective of the present study was to assess the relative contributions of whole-genome duplication, large-scale segmental duplication, and small-scale gene duplication in producing the extraordinary functional diversity of teleost Hbs. To accomplish this, we integrated phylogenetic reconstructions with analyses of conserved synteny to characterize the genomic organization and evolutionary history of the globin gene clusters of teleosts. These results were then integrated with available experimental data on functional properties and developmental patterns of stage-specific gene expression. Our results indicate that multiple α- and β-globin genes were present in the common ancestor of gars (order Lepisoteiformes) and teleosts. The comparative genomic analysis revealed that teleosts possess a dual set of TGD-derived globin gene clusters, each of which has undergone lineage-specific changes in gene content via repeated duplication and deletion events. Phylogenetic reconstructions revealed that paralogous genes convergently evolved similar functional properties in different teleost lineages. Consistent with other recent studies of globin gene family evolution in vertebrates, our results revealed evidence for repeated evolutionary transitions in the developmental regulation of Hb synthesis. |
| Databáze: | OpenAIRE |
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