Effects of low-dose metformin and rosiglitazone on biochemical, clinical, metabolic and biophysical outcomes in polycystic ovary syndrome
| Autor: | L. Mohiyiddeen, R. Berry, Krystallenia I Alexandraki, A. J. Watson, E. B. Jude, Nikolaos V. Apostolopoulos |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty endocrine system diseases medicine.medical_treatment Population Ovary Rosiglitazone Insulin resistance Internal medicine medicine Humans Hypoglycemic Agents Endothelial dysfunction education Ultrasonography education.field_of_study business.industry Insulin Obstetrics and Gynecology medicine.disease Polycystic ovary Metformin medicine.anatomical_structure Endocrinology Treatment Outcome Drug Therapy Combination Female Thiazolidinediones Endothelium Vascular business medicine.drug Polycystic Ovary Syndrome |
| Zdroj: | Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 33(2) |
| ISSN: | 1364-6893 |
| Popis: | The aim of this study was to compare the effect of low-dose metformin and rosiglitazone on clinical, biochemical, ultrasound features and endothelial function in patients with polycystic ovary syndrome (PCOS). After randomisation, a group of 17 women received metformin 500 mg b.d. (MG) and a group of 18 received rosiglitazone 4 mg o.d. (RG) for 3 months. Serum FSH, LH, testosterone, fasting glucose, insulin, IGF-1, IGFBP-3, CRP were measured at baseline and follow-up. Ovarian scan and microcirculation studies were also performed. It was found that there was a reduction in hyperandrogenaemia, insulin resistance, lipidaemia, CRP levels, ovarian volume and number of follicles in both groups. No improvement in endothelial- dependent function was noted but a significant improvement in endothelial-independent function in rosiglitazone group. It was concluded that low-dose therapeutic regimen with rosiglitazone and metformin, has comparable beneficial impacts on metabolic, hormonal and morphological features of PCOS but no obvious effect on vascular parameters in a population of predominantly mild PCOS. |
| Databáze: | OpenAIRE |
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