Prediabetes is associated with lower brain gray matter volume in the general population. The Study of Health in Pomerania (SHIP)
| Autor: | Robin Bülow, Stephan B. Felix, Wolfgang Rathmann, Nicole Werner, Hans-Jörgen Grabe, Katharina Wittfeld, Henry Völzke, Martin Bahls, S.E. Baumeister, Deborah Janowitz, Sabine Schipf, Till Ittermann, Marcello Ricardo Paulista Markus, U. Siewert-Markus, Marcus Dörr |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Blood Glucose Glycated Hemoglobin A endocrine system diseases Endocrinology Diabetes and Metabolism epidemiology [Prediabetic State] Medicine (miscellaneous) 030204 cardiovascular system & hematology Gastroenterology Impaired glucose tolerance 0302 clinical medicine Leukoencephalopathies Risk Factors Germany metabolism [Glycated Hemoglobin] Prevalence Prediabetes Gray Matter Aged 80 and over metabolism [Blood Glucose] education.field_of_study Glucose tolerance test Brain Diseases Nutrition and Dietetics blood [Biomarkers] medicine.diagnostic_test Fasting Middle Aged White Matter Magnetic Resonance Imaging diagnosis [Prediabetic State] Study of Health in Pomerania diagnostic imaging [Leukoencephalopathies] Female diagnostic imaging [Brain Diseases] Cardiology and Cardiovascular Medicine hormones hormone substitutes and hormone antagonists Adult medicine.medical_specialty metabolism [Glycated Hemoglobin A] Population epidemiology [Germany] Risk Assessment blood [Fasting] diagnostic imaging [White Matter] Prediabetic State 03 medical and health sciences Young Adult epidemiology [Brain Diseases] Internal medicine Diabetes mellitus medicine Humans ddc:610 education Aged Glycated Hemoglobin epidemiology [Leukoencephalopathies] business.industry diagnostic imaging [Gray Matter] nutritional and metabolic diseases Type 2 Diabetes Mellitus blood [Prediabetic State] Glucose Tolerance Test Impaired fasting glucose medicine.disease Endocrinology Cross-Sectional Studies Multivariate Analysis Linear Models hemoglobin A1c protein human business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Nutrition, metabolism and cardiovascular diseases 27(12), 1114-1122 (2017). doi:10.1016/j.numecd.2017.10.007 |
| DOI: | 10.1016/j.numecd.2017.10.007 |
| Popis: | We investigated the associations of fasting (FG) and 2-h postload (2HG) plasma glucose from oral glucose tolerance test (OGTT) with gray (GMV) and white (WMV) matter volume.We analyzed data from 1330 subjects without known diabetes mellitus, aged 21 to 81, from the second cohort (SHIP-Trend-0) of the population-based Study of Health in Pomerania (SHIP). Following the OGTT, individuals were classified in five groups (according to the American Diabetes Association criteria): normal glucose tolerance (NGT), isolated impaired fasting glucose (i-IFG), isolated impaired glucose tolerance (i-IGT), combined IFG and IGT (IFG + IGT) and unknown type 2 diabetes mellitus (UDM). GMV and WMV were determined by magnetic resonance imaging. FG, 2HG and OGTT groups were associated with GMV and WMV by linear regression models adjusted for confounders. FG and 2HG were inversely associated with GMV. The adjusted mean GMV, when compared with the NGT group (584 ml [95% CI: 581 to 587]), was significantly lower in the groups i-IFG (578 ml [95% CI: 573 to 582]; p = 0.035) and UDM (562 ml [95% CI: 551 to 573]; p 0.001), but not different in the i-IGT (586 ml [95% CI: 576 to 596]; p = 0.688) and IFG + IGT (579 ml [95% CI: 571 to 586]; p = 0.209) groups. There were no associations of FG, 2HG and OGTT parameters with WMV.Our findings suggest that elevated FG levels, even within the prediabetic range, might already have some harmful effects on GMV. |
| Databáze: | OpenAIRE |
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