The relationship between the dopaminergic system and depressive symptoms in cervical dystonia
| Autor: | Johannes D. Speelman, Marina A. J. Tijssen, Yasmine E. M. Dreissen, Jan Booij, Marenka Smit, Evelien Zoons |
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| Přispěvatelé: | Movement Disorder (MD), Graduate School, Other departments, ANS - Neurodegeneration, Radiology and Nuclear Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Dopamine SOCIAL ANXIETY DISORDER 0302 clinical medicine I-123-FP-CIT SPECT PARKINSONS-DISEASE Cervical dystonia Depression (differential diagnoses) Torticollis IN-VIVO Aged 80 and over biology Depression Dopaminergic General Medicine Middle Aged Pathophysiology humanities Radiology Nuclear Medicine and imaging Anesthesia SPECT Female Original Article medicine.symptom DopamineD2/3 receptor medicine.drug Adult medicine.medical_specialty 03 medical and health sciences Internal medicine mental disorders medicine Humans Radiology Nuclear Medicine and imaging Dopamine transporter Aged Tomography Emission-Computed Single-Photon business.industry Receptors Dopamine D2 Dopamine D2/3 receptor Receptors Dopamine D3 Binding potential OBSESSIVE-COMPULSIVE DISORDER medicine.disease 030227 psychiatry nervous system diseases EMISSION-TOMOGRAPHY Endocrinology nervous system MYOCLONUS-DYSTONIA Case-Control Studies biology.protein TRANSPORTER AVAILABILITY Dopamine transporter (DAT) SPASMODIC TORTICOLLIS PSYCHIATRIC COMORBIDITY business Myoclonus 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging, 44(8), 1375-1382. SPRINGER European journal of nuclear medicine and molecular imaging, 44(8), 1375-1382. Springer Verlag European Journal of Nuclear Medicine and Molecular Imaging |
| ISSN: | 1619-7089 1619-7070 |
| DOI: | 10.1007/s00259-017-3664-x |
| Popis: | Purpose Cervical dystonia (CD) is associated with tremor/jerks (50%) and psychiatric complaints (17–70%). The dopaminergic system has been implicated in the pathophysiology of CD in animal and imaging studies. Dopamine may be related to the motor as well as non-motor symptoms of CD. CD is associated with reduced striatal dopamine D2/3 (D2/3) receptor and increased dopamine transporter (DAT) binding. There are differences in the dopamine system between CD patients with and without jerks/tremor and psychiatric symptoms. Methods Patients with CD and healthy controls underwent neurological and psychiatric examinations. Striatal DAT and D2/3 receptor binding were assessed using [123I]FP-CIT and [123I]IBZM SPECT, respectively. The ratio of specific striatal to non-specific binding (binding potential; BPND) was the outcome measure. Results Twenty-seven patients with CD and 15 matched controls were included. Nineteen percent of patients fulfilled the criteria for a depression. Striatal DAT BPND was significantly lower in depressed versus non-depressed CD patients. Higher DAT BPND correlated significantly with higher scores on the Unified Myoclonus Rating Scale (UMRS). The striatal D2/3 receptor BPND in CD patients showed a trend towards lower binding compared to controls. The D2/3 BPND was significantly lower in depressed versus non-depressed CD patients. A significant correlation between DAT and D2/3R BPND was found in both in patients and controls. Conclusions Alterations of striatal DAT and D2/3 receptor binding in CD patients are related mainly to depression. DAT BPND correlates significantly with scores on the UMRS, suggesting a role for dopamine in the pathophysiology of tremor/jerks in CD. |
| Databáze: | OpenAIRE |
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