Progression of choriocapillaris flow deficits in clinically stable intermediate age-related macular degeneration
| Autor: | Srinivas R. Sadda, Giulia Corradetti, Liran Tiosano |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
genetic structures Retina Article Macular Degeneration 03 medical and health sciences 0302 clinical medicine Optical coherence tomography Age related Ophthalmology Humans Medicine Fluorescein Angiography medicine.diagnostic_test Choroid business.industry Infant Macular degeneration medicine.disease eye diseases 030221 ophthalmology & optometry sense organs business Tomography Optical Coherence 030217 neurology & neurosurgery |
| Zdroj: | Eye (Lond) |
| ISSN: | 1476-5454 0950-222X |
| Popis: | Purpose To evaluate the choriocapillaris (CC) flow deficit (FD) in eyes with stable intermediate age-related macular degeneration (AMD) eyes over 12 months of follow-up. Methods Thirty four patients with intermediate AMD were prospectively enrolled and evaluated by swept-source optical coherence tomography (SS-OCT) and OCT-angiography (OCTA) using the PLEX-Elite 9000. A 6 × 6 mm foveal-centered scan was used for both modalities and the study eyes were scanned twice to allow subsequent averaging. En face OCTA CC slabs (31-41 µm below the RPE-band) were exported and compensated for signal attenuation. Two compensated CC en-face images were registered and averaged prior to binarization and CC FD computation. The CC FD of the entire 6 × 6 macular region was quantified at baseline and at 12-months. The presence of high-risk features, namely intraretinal hyper-reflective foci (HRF), subretinal drusenoid deposits (SDD), and hyporeflective-core-drusen, were evaluated using SS-OCT volume scans. Results Among the 34 eyes, 25 eyes from 25 patients were noted on exam and OCT to remain stable as intermediate AMD at 12-months without the development of late AMD. Eleven eyes had high-risk features at baseline compared to 14 eyes at the end of the follow-up (p = 0.094). The mean ± SD FD% across the whole 6 × 6 macular region at baseline was 19.32 ± 4.64% and significantly increased to 28.62 ± 4.71% at the end of the study (p = 0.001). The CC FD progressed significantly both in non-HR and HR-eyes. Conclusions Choriocapillaris flow impairment significantly deteriorated over one year in relatively stable intermediate AMD. This might suggest that underlying progression of CC dysfunction occurs before structural changes appears on OCT and lead to the progression to late-stage AMD. |
| Databáze: | OpenAIRE |
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