The prevalence of human T‐lymphotropic virus type 1 & 2 (HTLV‐1/2) in South African blood donors

Autor: Ravi Reddy, Edward L. Murphy, Jabulisile Jaza, Olivier Cassar, Antoine Gessain, Charlotte Ingram, Marion Vermeulen, Charl Coleman, Colwyn Poole, Genevieve Jacobs, Wendy Sykes, Brian Custer, Zhanna Kaidarova, Carol Hlela
Přispěvatelé: South African National Blood Service (SANBS), Vitalant Research Institute [San Francisco], University of California [San Francisco] (UCSF), University of California, Red Cross Children's Hospital [Cape Town, South Africa], Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology (EPVO (UMR_3569 / U-Pasteur_3)), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), We would like to thank Vitalant Research Institute for partial funding and Abbott Diagnostics for providing a portion of the HTLV test kits. A special thanks to all the Donation Testing staff at SANBS for performing the testing in addition to their normal work. We would also like to thank Dr. Diana Hardie of the South African National Health Laboratory Service for performing the HTLV proviral DNA testing for confirmation of the Inno‐LIA results., University of California [San Francisco] (UC San Francisco), University of California (UC), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
[SDV]Life Sciences [q-bio]
Medical Physiology
Blood Donors
030204 cardiovascular system & hematology
Human T-lymphotropic virus
Serology
Blood donations
South Africa
0302 clinical medicine
MESH: South Africa
Seroepidemiologic Studies
Epidemiology
Prevalence
Mass Screening
donors
education.field_of_study
Human T-lymphotropic virus 1
MESH: Middle Aged
biology
Human T-lymphotropic virus 2
Blood Screening
Hematology
General Medicine
Middle Aged
3. Good health
MESH: Young Adult
Female
MESH: HTLV-II Infections
Adult
medicine.medical_specialty
Adolescent
Population
Clinical Sciences
serological testing
Article
03 medical and health sciences
Young Adult
MESH: HTLV-I Infections
medicine
Seroprevalence
Humans
MESH: Mass Screening
education
MESH: Prevalence
MESH: Adolescent
MESH: Seroepidemiologic Studies
MESH: Human T-lymphotropic virus 1
MESH: Humans
MESH: Human T-lymphotropic virus 2
business.industry
MESH: Blood Donors
MESH: Adult
Odds ratio
biology.organism_classification
HTLV-I Infections
MESH: Male
Cardiovascular System & Hematology
HTLV-II Infections
business
MESH: Female
030215 immunology
Demography
transfusion - transmissible infections
Zdroj: Vox Sanguinis
Vox Sanguinis, Wiley, 2019, 114 (5), pp.451-458. ⟨10.1111/vox.12778⟩
Vox sanguinis, vol 114, iss 5
Vox Sang
Vermeulen, Marion; Sykes, Wendy; Coleman, Charl; Custer, Brian; Jacobs, Genevieve; Jaza, Jabulisile; et al.(2019). The prevalence of human T-lymphotropic virus type 1 & 2 (HTLV-1/2) in South African blood donors.. Vox sanguinis. doi: 10.1111/vox.12778. UCSF: Retrieved from: http://www.escholarship.org/uc/item/7582w44x
Vox Sanguinis, 2019, 114 (5), pp.451-458. ⟨10.1111/vox.12778⟩
ISSN: 0042-9007
1423-0410
DOI: 10.1111/vox.12778⟩
Popis: Author(s): Vermeulen, Marion; Sykes, Wendy; Coleman, Charl; Custer, Brian; Jacobs, Genevieve; Jaza, Jabulisile; Kaidarova, Zhanna; Hlela, Carol; Gessain, Antoine; Cassar, Olivier; Poole, Colwyn; Ingram, Charlotte; Murphy, Edward L; Reddy, Ravi | Abstract: Background and objectivesDonated blood is not currently screened for human T-cell lymphotropic virus (HTLV) in South Africa. Several small studies have detected HTLV-1 in South Africa, but prevalence by geographic region or population group is unavailable.Materials and methodsWe performed a large seroprevalence study of South African blood donors during 3 months in 2013. All geographic regions except the Western Cape were included, and Black and Coloured (local term for mixed race) donors were oversampled. Identity-unlinked plasma samples were screened with the Abbott Prism HTLV-1/2 assay, and repeatedly reactive samples were tested by the Inno-LIA HTLV-1/2 Score confirmatory assay. Odds ratios were calculated with multivariable logistic regression.ResultsOf 46 752 donors tested, 133 (0·28%) were initially reactive, 111 (0·24%) repeatedly reactive and 57 (0·12%) confirmed positive for HTLV-1; none were HTLV-2 positive. Prevalence was 0·062% weighted to annual blood donations but highly concentrated in the Black population group (OR = 20·24 CI: 2·77-147·88); higher in females than males (OR = 1·81 CI: 1·06-3·08); and in donors aged g50 years compared to ages 16-19 (OR = 6·4 CI: 2·95-13·86). After controlling for age, sex and population group, there was no difference in prevalence between new and repeat blood donors or among geographic regions within South Africa.ConclusionsWe conclude that HTLV-1 infection is widespread among the Black population of South Africa and its epidemiology is similar to other endemic areas. Because South Africa is increasing its recruitment of Black blood donors, the implications for blood screening require further consideration.
Databáze: OpenAIRE
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