Geraniol attenuates oxidative stress, bioaccumulation, serological and histopathological changes during aluminum chloride-hepatopancreatic toxicity in male Wistar rats
| Autor: | Leila Beigom Hejazian, Negin Siahchehreh Badeli, Seyed Mohammad Hosseini, Reza Amani |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Antioxidant Necrosis Health Toxicology and Mutagenesis medicine.medical_treatment Acyclic Monoterpenes 010501 environmental sciences Pharmacology medicine.disease_cause 01 natural sciences Antioxidants chemistry.chemical_compound Chlorides medicine Environmental Chemistry Aluminum Chloride Animals Rats Wistar Aluminum Compounds 0105 earth and related environmental sciences chemistry.chemical_classification integumentary system Triglyceride Glutathione peroxidase General Medicine Malondialdehyde Pollution Bioaccumulation Rats Oxidative Stress chemistry Toxicity Lipid Peroxidation medicine.symptom Oxidative stress Geraniol Aluminum |
| Zdroj: | Environmental science and pollution research international. 27(16) |
| ISSN: | 1614-7499 |
| Popis: | Aluminum chloride (AlCl3) has different industrial applications including manufacturing paint and water treatment. The present study was designed to evaluate the alleviating effect of geraniol against AlCl3-induced hepatopancreatic toxicity. To this end, forty male Wistar rats were divided into control (0.9% NaCl, IP), geraniol (100 mg/kg orally), AlCl3 (70 mg/kg, IP), and AlCl3 (70 mg/kg, IP) plus geraniol (100 mg/kg orally) groups and then were treated daily for 28 days. Based on the results, serum cholesterol, triglyceride, as well as liver and pancreas enzymes increased significantly (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink