Functional, Clinical, and Sociodemographic Variables Associated with Risk of In-Hospital Mortality by COVID-19 in People over 80 Years Old
| Autor: | M. Méndez-Hinojosa, L. Furones-Fernández, M. Redondo-Martín, Á. Chen-Chim, P. Gil-Gregorio, Isabel Rodríguez-Sánchez, R. Saavedra-Palacios |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Multivariate analysis SARS-Cov-2 Protective factor Medicine (miscellaneous) Logistic regression functional status Cohort Studies older people blood parameters Risk Factors Internal medicine Activities of Daily Living Medicine Humans Hospital Mortality Aged Retrospective Studies Original Research Polypharmacy Aged 80 and over Nutrition and Dietetics business.industry COVID-19 Odds ratio medicine.disease mortality Confidence interval Hospitalization Pneumonia Spain Female Geriatrics and Gerontology business Cohort study |
| Zdroj: | The Journal of Nutrition, Health & Aging |
| ISSN: | 1760-4788 1279-7707 |
| Popis: | Objectives The objective is to assess the role of functional, clinical, and analytic parameters in predicting mortality in older patients hospitalized due to COVID-19. Design Cohort study with a mean follow-up of 12.8 days. Setting Public university hospital (Madrid, Spain). Participants 499 patients 80 and above consecutively admitted to a Spanish public university hospital between 4 March 2020 and 16 May 2020. Measurements Mortality was the main outcome. Data of sociodemographic variables (age, sex, living), comorbidities, polypharmacy, functional status, date of hospital admission and length of stay was recorded. Clinical symptoms, laboratory and X-ray findings were collected at time of admission. For multivariant analysis, logistic regressions were performed to identify risk factors for death. RESULTS: Mean age was 86.7±4.4 with 37% of death. Mortality was associated with male gender [odds ratio (OR) 1.50; 95% confidence interval (CI) 1.01–2.24], with a 5-points increase on Barthel Index [OR 1.01 (95%CI 1.00–1.02)], higher Charlson Index score [OR 1.13 (95%CI 1.02–1.26)] and comorbidities [OR 1.28 (95%CI 1.06–1.53)], hyperpolipharmacy [OR 2.00 (95%CI 1.04–3.82)], unilateral pneumonia [OR 1.83 (95%CI 1.01–3.30)], higher levels of C-reactive protein [OR 1.09 (95%CI 1.06–1.12)] and creatine [OR 1.48 (95%CI 1.15–1.89)]. Higher oxygen levels were a protective factor [OR 0.92 (95%CI 0.89–0.95)]. Conclusions Functional status, being male, a higher burden of comorbidities, hyperpolipharmacy, unilateral pneumonia and some laboratory parameters predict in-hospital mortality in this older population. The knowledge of these mortality risk factors should be used to improve the survival of older hospitalized patients. |
| Databáze: | OpenAIRE |
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