Isolation and Characterization of a Vibrio vulnificus Mutant Deficient in Both Extracellular Metalloprotease and Cytolysin
| Autor: | Chung-Ping Shao, Lien-I Hor, Ya Chi Ho, Jong-Jin Fan, Chun Keung Yu |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_treatment
Immunology Mutant Virulence Vibrio vulnificus Microbiology Mice Bacterial Proteins Vibrio Infections Tumor Cells Cultured medicine Animals Humans Vibrio Metalloproteinase Protease biology Cytotoxins Metalloendopeptidases biology.organism_classification Molecular Pathogenesis Infectious Diseases Mutation bacteria Parasitology Cytolysin |
| Zdroj: | Infection and Immunity. 69:5943-5948 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.69.9.5943-5948.2001 |
| Popis: | We isolated a Vibrio vulnificus mutant that was deficient in both metalloprotease and cytolysin by allelic exchange. The virulence of this mutant in mice and its cytotoxicity for HEp-2 cells were comparable to those of the wild-type strain, indicating that neither factor was essential for these properties. The cytolysin, but not the protease, seemed to be important for causing damage in the alimentary tract of the mice. |
| Databáze: | OpenAIRE |
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