Focal Epileptogenic Lesions in Adult Patients with Epilepsy and Generalized Epileptiform Discharges
| Autor: | Sang Kun Lee, Seo-Young Lee, Dong Wook Kim |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Generalized epileptiform discharges
Pediatrics medicine.medical_specialty medicine.diagnostic_test business.industry Dysembryoplastic Neuroepithelial Tumor Incidence (epidemiology) 05 social sciences Focal seizure Cortical dysplasia Electroencephalography medicine.disease Tertiary referral hospital 050105 experimental psychology Generalized epileptiform discharge 03 medical and health sciences Epilepsy 0302 clinical medicine medicine Secondary bilateral synchrony Original Article 0501 psychology and cognitive sciences Epilepsy surgery business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Epilepsy Research |
| ISSN: | 2233-6257 2233-6249 |
| DOI: | 10.14581/jer.16014 |
| Popis: | Background and Purpose There are reports of successful resective epilepsy surgery for pediatric patients with epilepsy and generalized epileptiform discharges when they had focal epileptogenic lesions identified by MRI. However, there is limited information regarding adult patients with epilepsy who have both generalized epileptiform discharges and focal epileptogenic lesions. Methods To investigate the incidence and characteristics of adult patients who have both generalized epileptiform discharges and potentially epileptogenic lesions, we retrospectively analyzed data of clinical features and results of EEG and MRI of all patients with adult-onset epilepsy in a tertiary referral hospital. Results While 1315 patients were classified as having partial seizures, 207 patients were classified as having generalized seizures. Five of 207 patients (2.4%) with generalized seizures had potentially epileptogenic lesions. All the epileptogenic lesions were congenital or acquired during early life, such as focal cortical dysplasia, dysembryoplastic neuroepithelial tumor, and cerebromalacic change because of perinatal injury. Conclusions The presence of epileptogenic lesions in adult patients with generalized epileptiform discharges may be an incidental finding, but it has been suggested that some adult-onset epilepsy with generalized epileptiform discharges may actually have focal onset, which may have significant clinical implications for the choice of appropriate treatment. |
| Databáze: | OpenAIRE |
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