| Autor: |
Anne E. Kiltie, Martin Kerr, Cheryl L. Scudamore, Ester M. Hammond, Sarah J. Jevons, Michael R.L. Stratford, James Thompson, Selvakumar Anbalagan, Jacqueline Kelly, Judith Nicholson, Jessica Gorrill, Helen Scott, Jia-Ling Ruan, Blaz Groselj |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1535-7163.22505310.v1 |
| Popis: |
A) Assessment of acute large bowel damage. CD1-nude mice treated with mock treatment or PAN (10 mg/kg) +/-IR. Lesions were scored semi-quantitatively using a 0-5 scale where 0 is no lesion present to 5 where the entire organ was affected by the pathology. B) Assessment of damage to intestine and bladder at 12 weeks. P=lesion present; scoring is semi-quantitative. Cage 2 mouse 1 was culled 2 days after being irradiated in error without the collimator present and cage 2 mouse 5 became unwell 7.5 weeks post-treatment and was culled, but no histopathological effects of the treatment were observed in the bowel. Cage 4 mouse 4 developed moderate diffuse ulcerative colitis. Amyloid was present in the small intestine of animals from all groups including the control group and is considered a pre-existing spontaneous lesion not related to the experimental protocol. Lesions were scored semi-quantitatively using a 0-5 scale where 0 is no lesion present to 5 where the entire organ was affected by the pathology. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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