Protection against Superoxide and Hydrogen Peroxide in Synovial Fluid from Rheumatoid Patients

Autor:	D. R. Blake, Barry Halliwell, D. A. Treby, N. D. Hall, J. M. C. Gutteridge
Rok vydání:	1981
Předmět:	biology Superoxide Dismutase Superoxide Radical chemistry.chemical_element Ascorbic Acid General Medicine Catalase Oxygen Arthritis Rheumatoid chemistry.chemical_compound chemistry Biochemistry Synovial Fluid Hyaluronic acid biology.protein Humans Synovial fluid Ceruloplasmin Hydrogen peroxide
Zdroj:	Clinical Science. 61:483-486
ISSN:	1470-8736 0143-5221
Popis:	1. On exposure of synovial fluid to superoxide and hydrogen peroxide, generated enzymically or by activated polymorphonuclear leucocytes, hyaluronic acid is depolymerized and the fluid loses its lubricating properties. The ability of synovial fluid from rheumatoid patients to scavenge superoxide and hydrogen peroxide was therefore examined. 2. Synovial fluid from a range of rheumatoid patients contained no superoxide dismutase activity, insufficient caeruloplasmin to scavenge any superoxide radical and little, if any, catalase activity. 3. Total ascorbate (reduced ascorbate + dehydroascorbate) concentrations in the plasma and synovial fluid of rheumatoid patients were similar in each case. The values are at the low end of the normal range. 4. These results are discussed in relation to the role of oxygen radicals in inflammatory joint disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c513cfe6d61f51a6157b4f3a7d7ab17 https://doi.org/10.1042/cs0610483 Zobrazit plný text záznamu