HyPE study: hydroxychloroquine prophylaxis-related adverse events’ analysis among healthcare workers during COVID-19 pandemic: a rising public health concern
| Autor: | Subhrakamal Saha, Treshita Dey, Mumtaz Ali Khan, Kishore Pratik, Debjyoti Dhar, Shah Dhiren Rutul, Thuppanattumadam Ananthasubramanian Sangeeth, Kalhalli Narayanaswamy Ramesh, Bada Sharanappa Nagaraja, Jayaram Manjula, Vikram Singh, Mahammad Samim Mondal |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty hydroxychloroquine Cross-sectional study Health Personnel Pneumonia Viral India Antiviral Agents Risk Assessment 03 medical and health sciences 0302 clinical medicine Risk Factors medicine Humans AcademicSubjects/MED00860 030212 general & internal medicine Adverse effect Pandemics Retrospective Studies 0303 health sciences 030306 microbiology business.industry Incidence Incidence (epidemiology) Public health Public Health Environmental and Occupational Health COVID-19 Retrospective cohort study Hydroxychloroquine General Medicine Middle Aged Confidence interval Cross-Sectional Studies Emergency medicine adverse effects Original Article Female prophylaxis Public Health Coronavirus Infections business Risk assessment medicine.drug |
| Zdroj: | Journal of Public Health Journal of Public Health (Oxford, England) |
| ISSN: | 1741-3850 1741-3842 |
| DOI: | 10.1093/pubmed/fdaa074 |
| Popis: | Background The rising burden of Coronavirus disease (COVID-19) has led to the mass use of hydroxychloroquine by healthcare workers (HCWs). Adverse event profile of this drug when used as prophylaxis is not well known in the literature. Methods A retrospective, cross-sectional study was conducted across the country using semi-structured web-based questionnaire among COVID-19 negative and asymptomatic healthcare workers, taking hydroxychloroquine prophylaxis. Descriptive and multivariate logistic-regression models were applied for analysis. Results Of the 166 participants, at least one adverse event was experienced by 37.9% participants, gastrointestinal being the most common (30.7%). Risk was higher in participants Conclusions A higher incidence of adverse events was observed when results were compared with studies involving patients on long-term hydroxychloroquine therapy. Younger age and first dose were associated with greater incidence of adverse events though all were self-limiting. Monitoring prior and during prophylaxis was inadequate even among those with cardiovascular disease and risk-factors. However, no serious cardiovascular events were reported. |
| Databáze: | OpenAIRE |
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