Leishmania donovanicyclin 1 (LdCyc1) forms a complex with cell cycle kinase subunit CRK3 (LdCRK3) and is possibly involved in S-phase-related activities
| Autor: | Pradeep Das, Abhik Sen, Sampali Banerjee, Partha Saha |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Cyclin D
Immunoblotting Cyclin A Protozoan Proteins Cyclin B Microbiology S Phase Cyclin-dependent kinase Cyclins CDC2 Protein Kinase Cyclin E parasitic diseases Genetics Animals Humans S-Phase Kinase-Associated Proteins Molecular Biology Cells Cultured Cyclin-dependent kinase 1 biology Gene Expression Profiling Cyclin-dependent kinase 3 Molecular biology Cell biology biology.protein Cyclin-dependent kinase complex Protein Kinases Cyclin A2 HeLa Cells Leishmania donovani |
| Zdroj: | FEMS Microbiology Letters. 256:75-82 |
| ISSN: | 1574-6968 0378-1097 |
| Popis: | Expression of Leishmania donovani cyclin 1 (LdCyc1) mRNA during the cell cycle of promastigotes is S-phase specific. Here, we show that the LdCyc1 protein is periodically expressed and the activity of its associated kinase varies during the cell cycle in line with its expression pattern. In addition, we have shown that LdCRK3, homologous to CRK3 from L. mexicana, is the cognate Cdk partner of LdCyc1 and that the activity of the complex is inhibited specifically by heat stable factor(s) from the parasite. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text