Additional file 3 of Liver X receptor-agonist treatment rescues degeneration in a Drosophila model of hereditary spastic paraplegia

Autor: Byrne, Dwayne J., Garcia-Pardo, M. Elena, Cole, Nelson B., Batnasan, Belguun, Heneghan, Sophia, Sohail, Anood, Blackstone, Craig, O’Sullivan, Niamh C.
Rok vydání: 2022
Předmět:
DOI: 10.6084/m9.figshare.19445641
Popis: Additional file 3: Supplementary Table 1. List of proteins identified as likely interactors of human ARL6IP1. This list of proteins was generated from the proteins pulled down with ARL6IP1-FLAG. Those included in this list had a spectral intensity abundance ratio (Arl6IP1-FLAG:Control) greater than 1.2 and were not identified in the CRAPome as non-specific binding partners within U-2 OS cells incubated with FLAG M2 affinity beads [48]. GO analysis was conducted to determine the localisation of ARL6IP1 binding partners and shown are proteins identified to have significant enrichment within ER, ER membrane or ER tubular network as determined by D = DAVID, P = Panther, FA = FuncAssociate, E = Enrichr. Proteins in bold were validated as ARL6IP1 interactors by independent co-immunoprecipitation and co-localisation experiments in this study. PSM: peptide spectrum matches.
Databáze: OpenAIRE