The use of LCP-Tacrolimus (Envarsus XR) in simultaneous pancreas and kidney (SPK) transplant recipients
| Autor: | Juan P. Rocca, Yorg Azzi, Jay A. Graham, Milan Kinkhabwala, Enver Akalin, Maria Ajaimy, Luz Liriano-Ward, Cindy Pynadath, Athena Konicki, Julia Torabi, Alesa Campbell |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Coefficient of variation 030232 urology & nephrology Urology 030230 surgery Tacrolimus 03 medical and health sciences chemistry.chemical_compound Postoperative Complications 0302 clinical medicine Diabetes mellitus medicine Humans In patient Dosing Glycated Hemoglobin Kidney Creatinine business.industry General Medicine medicine.disease Kidney Transplantation Transplant Recipients medicine.anatomical_structure chemistry Delayed-Action Preparations Female Surgery Pancreas Transplantation business Pancreas Immunosuppressive Agents |
| Zdroj: | The American Journal of Surgery. 219:583-586 |
| ISSN: | 0002-9610 |
| Popis: | Background Extended release LCP-tacrolimus (LCPT) allows once-daily dosing in transplant recipients. The improved bioavailability may be beneficial for simultaneous pancreas-kidney recipients (SPK). Methods This is a study of 39 SPK recipients on standard immediate-release tacrolimus (IR-TAC, n = 21) or LCPT (n = 18). Coefficient of variability (CV = 100∗standard deviation/mean) was calculated to assess drug levels. Hemoglobin A1c (HbA1c), tacrolimus and creatinine levels were measured postoperatively. Results There was no difference in tacrolimus CV in the IR-TAC and LCPT groups at 1 month or 3 months postoperatively; however, a greater difference was observed at 1 year (41.0 vs. 33.1%; p = 0.19). There were six episodes of acute rejection in the IR-TAC group compared to zero episodes in the LCPT group (p = 0.01). HbA1c was significantly higher in the IR-TAC group compared to LCPT at 3 (5.5 vs. 4.9%, p = 0.01), 6 (5.6 vs. 4.9%, p = 0.01) and 12 months (5.8 vs. 5.1%, p = 0.07). Conclusions Significantly lower rates of rejection were observed in patients receiving LCPT. The once daily dosing may facilitate medication adherence and result in improved long-term outcomes. |
| Databáze: | OpenAIRE |
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