Nanocomposites for X-Ray Photodynamic Therapy
| Autor: | Oleg I. Kit, Daria Kirsanova, Zaira Gadzhimagomedova, Alexander V. Soldatov, Peter V. Zolotukhin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
photosensitizer
medicine.medical_treatment Nanoparticle Photodynamic therapy Review 02 engineering and technology 01 natural sciences Nanocomposites Nanomaterials lcsh:Chemistry Mice reactive oxygen speeches scintillating nanoparticle Nanotechnology Incident energy Photosensitizer lcsh:QH301-705.5 Metal-Organic Frameworks Spectroscopy Photosensitizing Agents X-ray General Medicine 021001 nanoscience & nanotechnology Computer Science Applications photodynamic therapy 0210 nano-technology Modern medicine Materials science 010402 general chemistry Catalysis Inorganic Chemistry Cell Line Tumor medicine Animals Humans cancer Physical and Theoretical Chemistry Molecular Biology Nanocomposite Hydroxyl Radical X-Rays Organic Chemistry 0104 chemical sciences Oxygen Photochemotherapy lcsh:Biology (General) lcsh:QD1-999 Nanoparticles Reactive Oxygen Species Neoplasm Transplantation X-ray photodynamic therapy |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 4004, p 4004 (2020) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms21114004 |
| Popis: | Photodynamic therapy (PDT) has long been known as an effective method for treating surface cancer tissues. Although this technique is widely used in modern medicine, some novel approaches for deep lying tumors have to be developed. Recently, deeper penetration of X-rays into tissues has been implemented, which is now known as X-ray photodynamic therapy (XPDT). The two methods differ in the photon energy used, thus requiring the use of different types of scintillating nanoparticles. These nanoparticles are known to convert the incident energy into the activation energy of a photosensitizer, which leads to the generation of reactive oxygen species. Since not all photosensitizers are found to be suitable for the currently used scintillating nanoparticles, it is necessary to find the most effective biocompatible combination of these two agents. The most successful combinations of nanoparticles for XPDT are presented. Nanomaterials such as metal–organic frameworks having properties of photosensitizers and scintillation nanoparticles are reported to have been used as XPDT agents. The role of metal–organic frameworks for applying XPDT as well as the mechanism underlying the generation of reactive oxygen species are discussed. |
| Databáze: | OpenAIRE |
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