Involvement of Brd4 in different steps of the papillomavirus life cycle
| Autor: | Juliane Haedicke-Jarboui, Thomas Iftner, Shwu Yuan Wu, Cheng Ming Chiang |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Keratinocytes Cancer Research BRD4 Skin Neoplasms Transcription Genetic Carcinogenesis viruses Cell Cycle Proteins Biology Virus Replication Article 03 medical and health sciences Viral life cycle Transcription (biology) Virology Transcriptional regulation Humans Protein Phosphatase 2 Phosphorylation Casein Kinase II Transcription factor Papillomaviridae Genetics Papillomavirus Infections Nuclear Proteins Protein phosphatase 2 Oncogene Proteins Viral Cell biology Chromatin DNA-Binding Proteins 030104 developmental biology Infectious Diseases Gene Expression Regulation Host-Pathogen Interactions Casein kinase 2 Signal Transduction Transcription Factors |
| Zdroj: | Virus research. 231 |
| ISSN: | 1872-7492 |
| Popis: | Bromodomain-containing protein 4 (Brd4) is a cellular chromatin-binding factor and transcriptional regulator that recruits sequence-specific transcription factors and chromatin modulators to control target gene transcription. Papillomaviruses (PVs) have evolved to hijack Brd4's activity in order to create a facilitating environment for the viral life cycle. Brd4, in association with the major viral regulatory protein E2, is involved in multiple steps of the PV life cycle including replication initiation, viral gene transcription, and viral genome segregation and maintenance. Phosphorylation of Brd4, regulated by casein kinase II (CK2) and protein phosphatase 2A (PP2A), is critical for viral gene transcription as well as E1- and E2-dependent origin replication. Thus, pharmacological agents regulating Brd4 phosphorylation and inhibitors blocking phospho-Brd4 functions are promising candidates for therapeutic intervention in treating human papillomavirus (HPV) infections as well as associated disease. |
| Databáze: | OpenAIRE |
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