Effects of nano-sized titanium dioxide powder and ultraviolet light on superficial veins in a rabbit model
| Autor: | Hasan Gocmez, Ali Sefa Mendil, Ferit Kasimzade, Fatih Ada |
|---|---|
| Přispěvatelé: | Tıp Fakültesi, Göçmez, Hasan |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
animal model
titanium dioxide vein nano-TiO2 ultraviolet light Pathology medicine.medical_specialty Ultraviolet Rays Vein Medicine (miscellaneous) medicine.disease_cause General Biochemistry Genetics and Molecular Biology Nano-TiO2 chemistry.chemical_compound Internal Medicine medicine Ultraviolet light Animals Pharmacology (medical) Nano sized Telangiectasia Genetics (clinical) Titanium Titanium Dioxide medicine.anatomical_structure chemistry Reviews and References (medical) Titanium dioxide Rabbit model Photocatalysis Ultraviolet Light Rabbits Animal Model Powders medicine.symptom Ultraviolet |
| Popis: | Background. Titanium dioxide (TiO2) is widely used in many fields such as food, cosmetics, and paper industries. Studies on the photocatalytic properties of TiO2 on living tissue are limited. Objectives. To examine the histopathological effects of TiO2 solution on the marginal veins of rabbit ears under ultraviolet (UV) light. Materials and methods. In this study, 4 groups of rabbits (8 rabbits per group) were used: the 1st group was the control group, the 2nd group received 20% of nano-TiO2 only, the 3rd group received UV light only, and the 4th group received nano-TiO2 and UV light, simultaneously. The study lasted for 14 days and samples were taken from the marginal ear vein on the 15th day. Results. The ear tissues of rabbits in the control and TiO2 groups showed a normal histological appearance. In the UV group, the results showed severe chronic inflammation due to mononuclear cells around the hair follicles and perivascular areas. However, these findings decreased in the UV/nano-TiO2 group. Conclusions. The method applied in this study can be used in the treatment of telangiectasia in the future. However, this study investigating the effects of nano-TiO2 on vascular structures under UV light had a predominantly histological and observational nature. Further studies involving genetic, cytogenetic, biochemical, histochemical, and immunohistochemical analyses need to be performed to test the theories we proposed. © 2021 by Wroclaw Medical University |
| Databáze: | OpenAIRE |
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