Liver Fibrosis‐4 index indicates atrial fibrillation in acute ischemic stroke

Autor: Simon Fandler‐Höfler, Markus Kneihsl, Rudolf E. Stauber, Egbert Bisping, Harald Mangge, Gerit Wünsch, Melanie Haidegger, Linda Fabisch, Isra Hatab, Peter Fickert, David Werring, Christian Enzinger, Thomas Gattringer
Rok vydání: 2022
Předmět:
Zdroj: European Journal of Neurology. 29:2283-2288
ISSN: 1468-1331
1351-5101
Popis: Non-alcoholic fatty liver disease and particularly liver fibrosis are related to cardiovascular disease and may indicate an increased risk for atrial fibrillation (AF), but this association has not yet been systematically investigated in a cohort of ischemic stroke patients.We analyzed data from a prospective single-center study enrolling all consecutive ischemic stroke patients admitted to our stroke unit over a 1-year period. All patients received a thorough etiological workup. For evaluation of liver fibrosis, we determined the Fibrosis-4 (FIB-4) index, a well-established noninvasive liver fibrosis test. Laboratory results were analyzed from a uniform blood sample taken at stroke unit admission.Of 414 included patients (mean age 70.2 years, 57.7% male), FIB-4 indicated advanced liver fibrosis in 92 (22.2%). AF as the underlying stroke mechanism was present in 28.0% (large vessel disease: 25.6%, small vessel disease: 11.4%, cryptogenic: 29.2%). Patients with FIB-4 ≥ 2.67 had higher rates of AF (53.3% vs. 20.8%, p lt; 0.001), and this association remained significant after correction for established AF risk factors (odds ratio 2.53, 95% confidence interval 1.44-4.46, p = 0.001). FIB-4 was further associated with worse functional outcome 3 months (p lt; 0.001) and higher mortality 4 years post-stroke (p lt; 0.02), but these relationships were no longer present after correction for age and initial stroke severity. Moreover, FIB-4 was not associated with long-term recurrent vascular events.Liver fibrosis assessed by the FIB-4 index is independently associated with AF in acute ischemic stroke patients. Further studies should evaluate whether adding the FIB-4 index to AF risk scores increases their precision.
Databáze: OpenAIRE
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