[Metabolomic profiling in patients with metabolic syndrome]
| Autor: | E V Larcova, Yu N Belenkov, A A Maltseva, E O Korobkova, N V Khabarova, I S Ilgisonis, G. A. Shakaryants, M V Kozhevnikova, Alexey Kukharenko, Svetlana A. Appolonova |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
030204 cardiovascular system & hematology Pharmacology Serine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Metabolomics Metabolome Medicine Choline Humans In patient Amino Acids chemistry.chemical_classification Metabolic Syndrome business.industry medicine.disease Amino acid 030104 developmental biology Metabolomic profiling chemistry Metabolic syndrome Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Kardiologiia. 60(3) |
| ISSN: | 0022-9040 |
| Popis: | Objective. To identify biomarkers, which are most specific for patients with metabolic syndrome (MS) using metabolomic profiling.Materials and Methods. Metabolomic profiling of patients with MS and comparison of their profile with the profile of volunteers was performed using high-performance liquid chromatography-mass-spectrometry.Results. The metabolomic profile of MS patients differed in several amino acids, including choline, cysteine, and serine and in the acylcarnitine group (рConclusion. The metabolites most specific for MS patients were identified. Increased concentrations of a combination of amino acids and carnitines can be considered as possible additional risk factors for cardiovascular diseases. |
| Databáze: | OpenAIRE |
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