HPV seropositivity joints with susceptibility loci identified in GWASs at apoptosis associated genes to increase the risk of Esophageal Squamous Cell Carcinoma (ESCC)
| Autor: | Xianglin Yuan, Xiangning Fu, Zhaozhen Qi, Sheng Wei, Huanlei Wu, Wen Li, Guangyuan Hu, Huihua Xiong, Ju Yang, Qian Jiang, Zhongxing Liao |
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| Rok vydání: | 2014 |
| Předmět: |
Male
HPV16 Oncology Genome-wide association study Cancer Research medicine.medical_specialty Alcohol Drinking Esophageal Neoplasms Ubiquitin-Protein Ligases Drinking Apoptosis Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Serology Phosphoinositide Phospholipase C Esophageal squamous cell carcinoma Internal medicine Genotype Genetics medicine Humans Genetic Predisposition to Disease Risk factor neoplasms Aged Human papillomavirus 16 PLCE1 Papillomavirus Infections Smoking Odds ratio Middle Aged Single nucleotide polymorphism Genetic Loci Immunology Carcinoma Squamous Cell Female Serostatus Research Article |
| Zdroj: | BMC Cancer |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/1471-2407-14-501 |
| Popis: | Background We previously showed that human papillomavirus (HPV) serostatus was not an independent risk factor for esophageal squamous cell carcinoma(ESCC) in nonsmokers and nondrinkers; however, HPV increased the risk in smokers. Methods Here we investigated possible interactions between HPV16 serostatus and three susceptibility loci identified in GWASs at apoptosis associated genes with regard to risk of ESCC in a case–control study of 313 patients with ESCC and 314 healthy controls. The loci (CHK2 rs738722, C12orf51 rs2074356, and PLCE1 rs2274223) were genotyped, and the presence or absence of HPV16 in serum was measured by ELISA. Multivariable logistic regression was used to evaluate possible interactions of HPV16 serostatus and the three loci on the risk of ESCC. Results A significant interaction was found between HPV16 serology and rs2074356 (P = 0.005, odds ratio [OR] 1.40, 95% confidence interval [CI] 1.11–1.77) or rs2274223 (P |
| Databáze: | OpenAIRE |
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