Clinical Impact of Surgical Sarcopenia on Long-term Survival

Autor: Keisuke, Komori, Kazuki, Kano, Toru, Aoyama, Kentaro, Hara, Shinsuke, Nagasawa, Masato, Nakazono, Yota, Shimoda, Yukio, Maezawa, Yuta, Kumazu, Taiichi, Kawabe, Masakatsu, Numata, Tsutomu, Hayashi, Takanobu, Yamada, Hiroshi, Tamagawa, Tsutomu, Sato, Haruhiko, Cho, Norio, Yukawa, Yasushi, Rino, Takaki, Yoshikawa, Takashi, Ogata, Takashi, Oshima
Rok vydání: 2022
Předmět:
Zdroj: Anticancer Research. 42:4545-4552
ISSN: 1791-7530
0250-7005
DOI: 10.21873/anticanres.15957
Popis: Preoperative sarcopenia is associated with various cancers and affects the long-term prognosis of patients. After gastrectomy for gastric cancer, dynamic changes in body composition occur, and sarcopenia becomes more apparent after surgery than before surgery. However, the relationship between sarcopenia in the early postoperative period and long-term survival is not fully understood. The aim of this study was to determine the effects of surgical sarcopenia on long-term outcomes of patents with gastric cancer.We included 408 patients who underwent curative gastrectomy (distal or total gastrectomy) for gastric cancer at the Kanagawa Cancer Center from December 2013 to November 2017. Sarcopenia was defined using the skeletal muscle index (SMI), using computed tomography (CT) one month after gastrectomy. We compared the long-term outcomes between patients with and without sarcopenia.The 5-year overall survival (OS) rates were 83.2% and 91.4% in the surgical and non-surgical sarcopenia groups, respectively. The hazard ratio (HR) of surgical sarcopenia for OS was 2.410 (95% confidence interval (CI)=1.321-4.396). In addition, surgical sarcopenia was associated with non-cancer-related deaths and deaths from other cancers.Patients with surgical sarcopenia after gastrectomy should be carefully monitored not only for gastric cancer recurrence but also for the occurrence of other diseases, including other cancers.
Databáze: OpenAIRE
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