Effects of endocrine disruptor furan on reproductive physiology of Sprague Dawley rats: An F1 Extended One-Generation Reproductive Toxicity Study (EOGRTS)
| Autor: | Sarwat Jahan, Faiza Aman, P-O Thörnqvist, H Rehman, Muhammad Shoaib, M Jabbar, Imdad Ullah, N John |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Health Toxicology and Mutagenesis Physiology Endocrine Disruptors 010501 environmental sciences Biology Reproductive physiology Toxicology 01 natural sciences Rats Sprague-Dawley 03 medical and health sciences Pregnancy Testis Sprague dawley rats medicine Animals Weaning Testosterone Furans Toxicity Tests Chronic Progesterone 0105 earth and related environmental sciences Reproduction Ovary Estrogens General Medicine Luteinizing Hormone Diet Sprague dawley 030104 developmental biology Endocrine disruptor Prenatal Exposure Delayed Effects Female Histopathology Follicle Stimulating Hormone Reproductive toxicity |
| Zdroj: | Human & Experimental Toxicology. 39:1079-1094 |
| ISSN: | 1477-0903 0960-3271 |
| DOI: | 10.1177/0960327120911416 |
| Popis: | The present study investigated the reproductive toxicity of furan in an Extended One-Generation Reproductive Toxicity Study in rats. Sprague Dawley F0 weaning rats (30 per sex per group) were exposed to furan orally at 0, 1, 2.5, 5, and 10 mg kg−1 for 10 weeks (males) and 2 weeks (females) and then mated. Results of F0 indicated that in the furan-treated groups (5 mg kg−1 and 10 mg kg−1), body weight (bw) gain decreased during prebreed and gestational period while increased during lactation periods. F0 animals prebreeding exposure resulted in head tilt and foot splay at 10 mg kg−1. Number of live pups at birth were decreased ( p < 0.001) at 10 mg kg−1. At postnatal day (PND) 70, a significant ( p = 0.03) decrease in testosterone levels of male rats and estrogen levels of female rats ( p = 0.05) was observed in 10 mg kg−1 furan-treated group in F1 generation. Luteinizing hormone, follicle-stimulating hormone, and progesterone levels were also reduced, but their reduction was not statistically significant in all groups. In higher dose furan group (10 mg kg−1), testicular and ovarian weights were reduced in F1 generation at PND 70, with decreased daily sperm production ( p = 0.01) and disturbed estrous cyclicity ( p < 0.01). Some histopathological changes were also observed in testis and ovaries in groups whose parents were previously exposed to 10 mg kg−1 bw of furan group. Based on the above results, it is suggested that exposure to food-based contaminant furan induced remarkable changes in the F0 (parental stage) and F1 (offspring, pubertal, and adult stage) generations of Sprague Dawley rats. |
| Databáze: | OpenAIRE |
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