Growth, behavioural, serum biochemical and morphological changes in female rabbits fed high‐fat diet
| Autor: | Songjia Lai, Jie Wang, Xianbo Jia, Li Yanhong, Jiahao Shao, Tianfu Lai, Li Wang, Mingchuan Gan, Yuan Ma, Mauricio A. Elzo, Tao Tang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
040301 veterinary sciences medicine.medical_treatment Adipose tissue Diet High-Fat Subcutaneous fat 0403 veterinary science Food Animals Internal medicine Hyperlipidemia Adipocytes medicine Animals chemistry.chemical_classification Triiodothyronine business.industry Insulin Weight change 0402 animal and dairy science nutritional and metabolic diseases food and beverages Fatty acid High fat diet 04 agricultural and veterinary sciences medicine.disease 040201 dairy & animal science Endocrinology Adipose Tissue chemistry Female Animal Science and Zoology Rabbits business |
| Zdroj: | Journal of Animal Physiology and Animal Nutrition. 105:345-353 |
| ISSN: | 1439-0396 0931-2439 |
| Popis: | This study aimed to determine whether high-fat diet (HFD) could cause growth, behavioural, biochemical and morphological changes in young female rabbits. Thirty-six female rabbits were randomly divided into two groups fed with either a high-fat diet (HFD) or a standard normal diet (SND) for 5 weeks. Growth and behavioural changes were recorded during the 5-week feeding period. Tissue samples, including blood and adipose tissue, were obtained after slaughter. HFD rabbits weighed more by the end of the feeding period, had a higher percent body weight and adipose tissue weight change and had longer body and bust lengths than SND rabbits. HFD rabbits significantly reduced their feed intake and feeding frequency during the fourth and fifth weeks. HFD rabbits also showed lower frequency of drinking and resting and increased stereotypical behaviour. Besides, HFD rabbits showed significant physiological abnormalities. HFD rabbits had higher serum cholesterol (TC) and triglycerides (TG) levels than SND rabbits at the end of the feeding period, and higher free fatty acid (FFA) levels than rabbits in the SND group after the third week of feeding. Serum thyroxine (T4) increased significantly in week 2 and week 5 and triiodothyronine (T3) increased significantly in week four. However, there was no significant change in serum glucose (GLU) and insulin (INS) levels. Additionally, HFD reduced the area and diameter of perirenal and subcutaneous fat cells and increased their density. Our findings suggest that HFD rabbits had higher weight gains, accumulation of fat, and more behavioural changes than SND rabbits. Although high levels of fat in the diet had a low impact on hyperglycaemia, it could lead to hyperlipidemia and hyperthyroidism. Our results also suggest that sustained HFD may cause the proliferation of adipocytes in young female rabbits. |
| Databáze: | OpenAIRE |
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