Monoclonal antibodies directed to the erbB-2 receptor inhibit in vivo tumour cell growth
| Autor: | J. Schlegel, N. E. Hynes, W. Wels, I M Harwerth, M. Müller |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: |
Cancer Research
medicine.medical_specialty medicine.drug_class Receptor ErbB-2 medicine.medical_treatment Down-Regulation Mice Nude Breast Neoplasms Monoclonal antibody 3T3 cells Mice Cell surface receptor Internal medicine Proto-Oncogene Proteins medicine Biomarkers Tumor Cell Adhesion Tumor Cells Cultured Animals Humans Receptor Cell Line Transformed Ovarian Neoplasms Mice Inbred BALB C biology Cell growth Antibodies Monoclonal Immunotherapy 3T3 Cells ErbB Receptors medicine.anatomical_structure Endocrinology Oncology Cell culture biology.protein Cancer research Female Antibody Cell Division Neoplasm Transplantation Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 5160-1516 |
| Popis: | Four monoclonal antibodies (MAbs) specific for the extracellular domain of the human erbB-2/HER2 protein (FRP5, FSP16, FWP51 and FSP77) have been isolated (Harwerth et al., J. Biol. Chem., 267, 15160-15167, 1992). In this paper we describe the effects of erbB-2 specific MAb administration on the tumorigenic growth of human erbB-2 transformed NIH3T3 cells implanted into athymic nude mice. Two antibodies, FWP51 and FSP77, inhibited the onset of tumour growth, while the administration of FRP5 and FSP16 did not affect tumour growth. In addition, administration of MAbs FWP51 and FSP77 led to a retardation in the growth of established tumours. Treatment was not curative in that tumours regrew within two weeks of the final treatment. The administration of a combination of MAbs FWP51 and FSP77 which react with two distinct regions on the erbB-2 molecule was more effective than treatment with either MAb alone. The two growth-inhibitory antibodies were also effective in the treatment of tumours established from SKOV3 cells, a human ovarian tumour cell line with high levels of the erbB-2 protein. The effect of the MAbs on the anchorage-independent growth of erbB-2 transformed cells and on erbB-2 receptor turnover was also measured. Images Figure 5 |
| Databáze: | OpenAIRE |
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