Tachykinins and ovarian function in mammals
| Autor: | Luciano Debeljuk |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
endocrine system
medicine.medical_specialty animal structures Physiology medicine.drug_class Ovary Substance P Luteal phase Biology digestive system complex mixtures Biochemistry Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology Tachykinins Internal medicine medicine Animals Mammals musculoskeletal neural and ocular physiology Follicular fluid medicine.anatomical_structure chemistry Female Neurokinin A Gonadotropin Gonadotropins Endocrine gland Hormone |
| Zdroj: | Peptides. 27:736-742 |
| ISSN: | 0196-9781 |
| Popis: | Tachykinins are bioactive peptides whose presence has been demonstrated in endocrine glands, where they likely exert a paracrine modulatory activity on hormonal secretions. In the ovary, tachykinins have been shown to be present in nerve fibers, blood vessels, and in granulosa, luteal and interstitial cells. Tachykinin gene expression was shown in granulosa and luteal cells. Tachykinins have also been found in the follicular fluid. Substance P (SP) has been demonstrated to significantly affect the release of hormonal steroids by ovarian cells in vitro. While some authors found that SP stimulated the release of steroids, others found an inhibitory effect by the same tachykinin. Gonadotropins decrease tachykinin concentrations in the ovary. The neonatal treatment of rats with capsaicin, a drug that depletes SP in primary afferent neurons, resulted in a modest reduction in the reproductive success in rats. The experimental results listed in this review suggest that tachykinins are synthesized in the ovary, in the granulosa and luteal cells. Tachykinins are likely intraovarian modulators of the secretion of hormonal steroids. Their stores in the ovary are likely regulated by pituitary gonadotropins. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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