ProteoVision: web server for advanced visualization of ribosomal proteins
| Autor: | Maria Ahmad, Vasanta L Chivukula, Caeden D. Meade, Aparna Maddala, Holly M McCann, Aakash Sharma, Anton S. Petrov, Burak Gulen, Claudia Alvarez-Carreño, Chad R. Bernier, Loren Dean Williams, Petar I. Penev |
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| Rok vydání: | 2021 |
| Předmět: |
Models
Molecular Ribosomal Proteins Internet Web server Multiple sequence alignment Information retrieval AcademicSubjects/SCI00010 Protein Conformation Protein domain Sequence alignment Peptide Elongation Factor Tu Biology computer.software_genre Visualization Acetolactate Synthase Upload Protein structure Bacterial Proteins Scripting language Web Server Issue Genetics Sequence Alignment computer Software |
| Zdroj: | Nucleic Acids Research |
| ISSN: | 1362-4962 0305-1048 |
| DOI: | 10.1093/nar/gkab351 |
| Popis: | ProteoVision is a web server designed to explore protein structure and evolution through simultaneous visualization of multiple sequence alignments, topology diagrams and 3D structures. Starting with a multiple sequence alignment, ProteoVision computes conservation scores and a variety of physicochemical properties and simultaneously maps and visualizes alignments and other data on multiple levels of representation. The web server calculates and displays frequencies of amino acids. ProteoVision is optimized for ribosomal proteins but is applicable to analysis of any protein. ProteoVision handles internally generated and user uploaded alignments and connects them with a selected structure, found in the PDB or uploaded by the user. It can generate de novo topology diagrams from three-dimensional structures. All displayed data is interactive and can be saved in various formats as publication quality images or external datasets or PyMol Scripts. ProteoVision enables detailed study of protein fragments defined by Evolutionary Classification of protein Domains (ECOD) classification. ProteoVision is available at http://proteovision.chemistry.gatech.edu/. Graphical Abstract Graphical AbstractProteoVision is a webserver designed to visualize phylogenetic, structural, and physicochemical properties of proteins by integration of four mutually synchronized applets that visually represent map data for each amino-acid simultaneously on levels of a (i) multiple sequence alignment; (ii) secondary structure; (iii) 3D structure and (iv) frequency box plot graph. |
| Databáze: | OpenAIRE |
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