Investigation of Amphibian Mortality Events in Wildlife Reveals an On-Going Ranavirus Epidemic in the North of the Netherlands
| Autor: | Rijks, Jolianne M, Saucedo, Bernardo, Spitzen-van der Sluijs, Annemarieke, Wilkie, Gavin S, van Asten, Alphons J A M, van den Broek, Jan, Boonyarittichaikij, Roschong, Stege, Marisca, van der Sterren, Fleur, Martel, An, Pasmans, Frank, Hughes, Joseph, Gröne, Andrea, van Beurden, Steven J, Kik, Marja J L, Veterinair Pathologisch Diagnostisch Cnt, LS Pathologie, dPB I&I, Infection & Immunity, dFAH AVR, Applied Veterinary Research |
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| Přispěvatelé: | Veterinair Pathologisch Diagnostisch Cnt, LS Pathologie, dPB I&I, Infection & Immunity, dFAH AVR, Applied Veterinary Research |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pelobates fuscus Ranavirus MAJOR CAPSID PROTEIN Animal Phylogenetics Pathology and Laboratory Medicine DISEASE Geographical Locations 0403 veterinary science Larvae MOLECULAR Medicine and Health Sciences IRIDOVIRUS Phylogeny Netherlands Data Management Multidisciplinary biology Ecology Spadefoot toad 04 agricultural and veterinary sciences DNA Virus Infections 3. Good health Europe Phylogenetics Vertebrates Medicine Sequence Analysis Research Article PELOPHYLAX KL. ESCULENTUS Amphibian Computer and Information Sciences food.ingredient 040301 veterinary sciences Iridovirus Science MODELS Animals Wild Research and Analysis Methods Toads Amphibians Necrosis 03 medical and health sciences Signs and Symptoms food Midwife toad FISH Diagnostic Medicine biology.animal Animals Evolutionary Systematics Veterinary Sciences Molecular Biology Techniques Sequencing Techniques Epidemics Molecular Biology Taxonomy Evolutionary Biology Metamorphosis Organisms Outbreak Biology and Life Sciences biology.organism_classification 030104 developmental biology People and Places Threatened species CHARACTERIZATION Zoology Sequence Alignment Developmental Biology |
| Zdroj: | PLoS ONE, Vol 11, Iss 6, p e0157473 (2016) PLOS ONE PLoS ONE PLoS One, 11(6), 1. Public Library of Science |
| ISSN: | 1932-6203 |
| Popis: | In the four years following the first detection of ranavirus (genus Ranavirus, family Iridoviridae) infection in Dutch wildlife in 2010, amphibian mortality events were investigated nationwide to detect, characterize and map ranaviruses in amphibians over time, and to establish the affected host species and the clinico-pathological presentation of the disease in these hosts. The ultimate goal was to obtain more insight into ranavirus disease emergence and ecological risk. In total 155 dead amphibians from 52 sites were submitted between 2011 and 2014, and examined using histopathology, immunohistochemistry, virus isolation and molecular genetic characterization. Ranavirus-associated amphibian mortality events occurred at 18 sites (35%), initially only in proximity of the 2010 index site. Specimens belonging to approximately half of the native amphibian species were infected, including the threatened Pelobates fuscus (spadefoot toad). Clustered massive outbreaks involving dead adult specimens and ranavirus genomic identity indicated that one common midwife toad virus (CMTV)-like ranavirus strain is emerging in provinces in the north of the Netherlands. Modelling based on the spatiotemporal pattern of spread showed a high probability that this emerging virus will continue to be detected at new sites (the discrete reproductive power of this outbreak is 0.35). Phylogenetically distinct CMTV-like ranaviruses were found in the south of the Netherlands more recently. In addition to showing that CMTV-like ranaviruses threaten wild amphibian populations not only in Spain but also in the Netherlands, the current spread and risk of establishment reiterate that understanding the underlying causes of CMTV-like ranavirus emergence requires international attention. |
| Databáze: | OpenAIRE |
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